Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New active compound identified in treatment of malaria

15.10.2007
Malaria is caused by Plasmodium parasites and it is the female Anopheles mosquito that acts as a vector for these malarial parasites in to the human body.

Each year, 200 to 400 million people are infected in the underdeveloped and developing regions of the planet, causing the death of between 2 to 3 million of their inhabitans, most of which are children below 5 years of age. Several therapeutic agents that efficiently fight the disease already exist, but nevertheless; there is still a need to develop new antimalarial drugs to increase the therapeutic arsenal against the disease and to help prevent the different strains of already resistant Plasmodium parasites from acquiring further resistance to antimalarial drugs.

The Universidad Autónoma de Barcelona and the Universidad Complutense de Madrid have patented a new active compound for the treatment of malaria.

The researchers have also identified the gene where this compound inhibits the growth of the parasite, since it has a crucial role in its cycle inside the erythrocytes. The new compound is a non digestive protease inhibitor that does not allow the growth or development of the Plasmodium parasite inside the erythrocytes. This active compound, even considering its peptide origin, is expected to improve the activity and bioavailability of the drugs.

The identification of specific targets essential for the development of the parasite is an effective tool to facilitate the development of new drugs that cure infections by parasites resistant to current antimalarial drugs. The target identified, is a single gene with a very specific role for the parasite, and that is conserved and shared among all the species of plasmodium, which potentially implies a low probability for acquiring resistance. Also, the human host has several homologous genes to this target gene, but with different properties to the parasitic one, which is the possible reason for nearly non existent toxic effects of the new active compound in the mice used to test the drug, lending an additional advantage to this patented compound.

Área de Cultura Científica | alfa
Further information:
http://www.ucm.es

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>