Dr Colin P. McCoy and colleagues from the School of Pharmacy at Queen’s describe their new molecular-scale dosing devices as “a new paradigm for precise control of drug dosing using light.”
The devices consist of medications combined with certain chemical compounds that respond to light in ways that release precisely controlled amounts of the drug. Drug release begins when light falls on the compounds, and lasts only as long as the light continues to shine.
Their study, which is reported in the Journal of the American Chemical Society, showed successful laboratory tests of the system in the controlled release of three common medications used to treat pain and inflammation — aspirin, ibuprofen and ketoprofen.
Explaining some of the potential uses for the new method, Dr McCoy said: “One potential use we cited in the study would be in the treatment of urinary catheter infections, where the drug is held latently in the catheter, and is released when needed using light from a fibre optic. The system could likewise be used for other conditions using an implant under the skin for precisely controlled drug dosing.”
Lisa Mitchell | alfa
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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23.05.2017 | Event News
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26.05.2017 | Life Sciences
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