Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Activated immune system attacks brain after stroke

03.08.2007
Research recently presented to an academic audience at LifeSciences 2007, shows that the body’s own natural defences can actually worsen the brain damage caused by a stroke. Life Sciences 2007 is the first joint meeting of the Biochemical Society, the British Pharmacological Society and The Physiological Society.

The study by Dr Barry McColl, Dr Stuart Allan and Professor Dame Nancy Rothwell at The University of Manchester suggests a way in which an immune system that has already been activated by an infection elsewhere in the body can target the vulnerability of the brain following a stroke.

The team’s findings, which have been viewed to date only by an academic audience, may have important implications for the elderly, who are most at risk of stroke and frequently suffer from infection and other conditions, such as atherosclerosis, that stimulate the immune system.

Stroke – the brain equivalent of a heart attack – is the UK’s third biggest killer as well as the leading cause of disability, affecting 150,000 people every year. It costs the health service £2.8billion a year in direct care costs and accounts for 6.5% of total NHS and social services expenditure. There are currently no treatments available.

“Our study suggests that if the immune system is already primed by an infection or another stimulus when stroke occurs, then the outcome of the stroke will be worse,” said Dr McColl, who is based in Manchester’s Faculty of Life Sciences.

“Tests on mice given a stimulus to mimic bacterial infection and activate their immune system showed they suffered more than twice the amount of cell death in the brain following a stroke compared to mice that were given a placebo.

“The study’s findings are particularly significant because a recent study has shown that the chances of having a stroke are increased after infection. However, it will be important to confirm these results in further studies.”

The group also discovered that a population of white blood cells, called neutrophils, that normally fight infection by killing bacteria, was responsible for the increased brain damage. Mice in which neutrophils were depleted did not develop as much damage.

The results – published in the Journal of Neuroscience – indicate that other conditions, like obesity and tooth decay, which trigger similar immune responses to infections, might also increase the severity of brain damage caused by stroke.

“Knowing exactly how the underlying activation status of the immune system affects stroke will help to develop new ways of combating the damage caused by stroke,” said Dr McColl.

“This could have serious implications for the way stroke patients are treated in the future. For example, anti-inflammatory drugs that are currently being tested in human trials may be able to dampen the activated immune system and so reduce brain damage.”

Lucy Fielden | alfa
Further information:
http://www.lifesciences2007.org/

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>