Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Activated immune system attacks brain after stroke

03.08.2007
Research recently presented to an academic audience at LifeSciences 2007, shows that the body’s own natural defences can actually worsen the brain damage caused by a stroke. Life Sciences 2007 is the first joint meeting of the Biochemical Society, the British Pharmacological Society and The Physiological Society.

The study by Dr Barry McColl, Dr Stuart Allan and Professor Dame Nancy Rothwell at The University of Manchester suggests a way in which an immune system that has already been activated by an infection elsewhere in the body can target the vulnerability of the brain following a stroke.

The team’s findings, which have been viewed to date only by an academic audience, may have important implications for the elderly, who are most at risk of stroke and frequently suffer from infection and other conditions, such as atherosclerosis, that stimulate the immune system.

Stroke – the brain equivalent of a heart attack – is the UK’s third biggest killer as well as the leading cause of disability, affecting 150,000 people every year. It costs the health service £2.8billion a year in direct care costs and accounts for 6.5% of total NHS and social services expenditure. There are currently no treatments available.

“Our study suggests that if the immune system is already primed by an infection or another stimulus when stroke occurs, then the outcome of the stroke will be worse,” said Dr McColl, who is based in Manchester’s Faculty of Life Sciences.

“Tests on mice given a stimulus to mimic bacterial infection and activate their immune system showed they suffered more than twice the amount of cell death in the brain following a stroke compared to mice that were given a placebo.

“The study’s findings are particularly significant because a recent study has shown that the chances of having a stroke are increased after infection. However, it will be important to confirm these results in further studies.”

The group also discovered that a population of white blood cells, called neutrophils, that normally fight infection by killing bacteria, was responsible for the increased brain damage. Mice in which neutrophils were depleted did not develop as much damage.

The results – published in the Journal of Neuroscience – indicate that other conditions, like obesity and tooth decay, which trigger similar immune responses to infections, might also increase the severity of brain damage caused by stroke.

“Knowing exactly how the underlying activation status of the immune system affects stroke will help to develop new ways of combating the damage caused by stroke,” said Dr McColl.

“This could have serious implications for the way stroke patients are treated in the future. For example, anti-inflammatory drugs that are currently being tested in human trials may be able to dampen the activated immune system and so reduce brain damage.”

Lucy Fielden | alfa
Further information:
http://www.lifesciences2007.org/

More articles from Health and Medicine:

nachricht The end of pneumonia? New vaccine offers hope
23.10.2017 | University at Buffalo

nachricht Scientists track ovarian cancers to site of origin: Fallopian tubes
23.10.2017 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>