The results are now being published in Cancer Research and are part of a project funded by the Austrian Science Fund FWF. The antibodies produced during the project belong to a class that also plays a key role in the development of allergic reactions. Consequently, the results will be a key focal point at the 1st International AllergoOncology Symposium, which is to be held today in Vienna, Austria.
People who suffer from allergies are well acquainted with immunoglobulin E (IgE). It is this class of antibodies that plays a key role in causing an allergy sufferer's immune system to overreact. Oncologists too are very familiar with IgE. Numerous in-depth studies have shown that those with raised levels of IgE are much less likely to suffer from certain types of cancer. Or in other words – allergy sufferers are at a lower risk of developing cancer.
ALLERGY & CANCER
"In actual fact, the IgE produced during an allergic reaction does not attack cancer tumours but instead attacks allergens, for example pollen", explains the study's leader, Prof. Erika Jensen-Jarolim, head of the Department of Pathophysiology at the Medical University of Vienna. "The fact that IgE nevertheless acts against tumours is more of a fortunate side-effect of the highly efficient characteristic of this antibody class. It was our aim to make this antibody class, which is typical for allergies, act directly against tumours. At the same time, we wanted to encourage the long-term production of IgE in the body by means of active immunisation."
Prof. Jensen-Jarolim's group recently succeeded in achieving the latter – active immunisation against certain types of tumour – in mice. However, due to the selected type of immunisation (injection below the abdominal wall) the antibodies that were produced belonged to the IgG class. This type of antibody produces a much more limited and shorter-term effect against tumours than IgE antibodies.
THROUGH THE STOMACH
Prof. Jensen-Jarolim used one of her group's earlier successes – achieved as part of another FWF project on food allergies – to ensure that immunisation resulted in the intended activation of IgE. These findings prove that food proteins are effective in inducing IgE-dependent immune reactions when they withstand the acidic environment of the stomach.
Prof. Jensen-Jarolim's team therefore fed mice a peptide very similar to a tumour peptide while reducing acidification in the stomach, thereby hindering digestion of the peptide. As a result, a type of allergic reaction was triggered against this tumour-like peptide – the mice produced tumour-specific IgE antibodies. The result is the world’s first active IgE-stimulating tumour vaccination.
From Prof. Jensen-Jarolim's point of view, the publication of this work in Cancer Research comes at a the perfect time – just as the 1st International AllergoOncology Symposium starts on 16th April in Vienna. This symposium, which she initiated and organised, will be the first time that specialists from the U.K., France, Italy, Canada, Austria and the U.S. have been brought together to analyse and discuss the links between allergies and cancer. The topics under discussion range from the use of allergic reactions to treat cancer to the application of mimotopes for active immunisation against cancer tumours. By providing ongoing support for their work, the FWF has also helped establish this new medical field in Austria and on a global scale.
Image and text will be available online from Monday, 16th April 2007, 09.00 a.m. CET onwards: http://www.fwf.ac.at/en/public_relations/press/pv200704-en.html
Till C. Jelitto | alfa
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News