In an article in the December issue of The American Journal of Medicine, researchers describe the diagnostic pathways that can be used to achieve an accurate and safe diagnosis of PE.
Based on the results from the Prospective Investigation of Pulmonary Embolism Diagnosis II (PIOPED II) and other studies, these guidelines include both evidence-based recommendations and opinions based on information available at this time.
Writing in the article, Paul D. Stein, MD, states “[we] recommend stratification of all patients with suspected pulmonary embolism according to an objective probability assessment. A negative D-dimer rapid ELISA with a low or moderate probability clinical assessment can safely exclude pulmonary embolism. If pulmonary embolism is not excluded, CT angiography/CT venography is recommended by most PIOPED II investigators, although CT angiography alone is an option. In patients with discordant findings on clinical assessment and CT imaging, further evaluation depends on clinical judgment. In pregnant women and women of reproductive age, ventilation/perfusion scans are recommended by many PIOPED II investigators as the first imaging test.”
In an accompanying commentary, James E. Dalen, MD, MPH, describes how various techniques for the diagnosis of PE have been introduced over the last 40 years, each with advantages and disadvantages in accuracy, risk to the patient and cost. Writing about the article, he states, “These recommendations from the PIOPED investigators will have a major impact on the diagnosis and treatment of pulmonary embolism.”
The study is “Diagnostic Pathways in Acute Pulmonary Embolism: Recommendations of The PIOPED II Investigators” by Paul D. Stein, MD, Pamela K. Woodard, MD, John G. Weg, MD, Thomas W. Wakefield, MD, Victor F. Tapson, MD, H. Dirk Sostman, MD, Thomas A. Sos, MD, Deborah A. Quinn, MD, Kenneth V. Leeper, Jr, MD, Russell D. Hull, MBBS, MSc, Charles A. Hales, MD, Alexander Gottschalk, MD, Lawrence R. Goodman, MD, Sarah E. Fowler, PhD, and John D. Buckley, MD, MPH. The commentary is “Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED I, II, and III) and the Diagnosis of Pulmonary Embolism” by James E. Dalen, MD, MPH. These appear in The American Journal of Medicine, Volume 119, Issue 12 (December 2006), published by Elsevier.
Pamela Poppalardo | alfa
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Physics and Astronomy
26.10.2016 | Earth Sciences
25.10.2016 | Earth Sciences