For unknown reasons, 5-10 percent of people who experience a concussion have symptoms that persist beyond six weeks. These people are diagnosed with post-concussion syndrome (PCS). Previously there has been no treatment for the condition with proven success.
"The most common approach by physicians is to recommend no exercise and prescribe antidepressants," said Barry Willer, Ph.D., UB professor of psychiatry and rehabilitation sciences. Willer is lead author on the paper describing the new method, published in the September issue of Current Treatment Options in Neurology.
"Most people with PCS have symptoms of depression," said Willer, "so anti-depressant treatment makes sense. However, antidepressants do little more than relieve some of the depression symptoms. We were interested in a treatment that didn't just treat the symptoms, but actually improved the patient's brain function."
The researchers call their new treatment "regulated exercise." The approach consists of determining the ideal exercise program for each athlete based on a number of individual physiological indicators at baseline.
Patients are tested every two to three weeks with specialized equipment at the sports medicine clinic to determine their progress, and a new program is developed based on those results.
Willer and co-author John Leddy, M.D., clinical associate professor of orthopaedics and rehabilitation sciences, indicated it is too early to call the treatment a cure, but they are optimistic about the results so far.
The researchers described the treatment method in mid-September at the 2006 Brain Injury Conference of the Americas in Miami, where the response was very favorable, according to Willer.
"Professionals at the meeting were delighted that our approach to treatment of post-concussion syndrome doesn't involve any medications and is very cost-efficient. We were surprised to learn that we are among only a few investigators interested in people with symptoms that won't go away.
"There is no other known treatment specifically for PCS, which we define as persistent symptoms of concussion past the time they should have cleared, usually around three weeks," said Willer. "As far as we can determine, there is only one other group in North America that is using regulated exercise as part of the treatment for PCS."
Willer and Leddy have used regulated exercise successfully with people who were as much as six months post-concussion. Their regimen is based on the hypothesis that the regulatory system responsible for maintaining cerebral blood flow, which may be dysfunctional in people with a concussion, can be restored to normal by controlled, graded symptom-free exercise.
"The treatment program is well tolerated by patients" Willer said. "Just being able to exercise often reduces the depressive symptoms. But it's imperative that the patient not go beyond the exercise limits.
"After the first three weeks of regulated exercise, we reassess the patient to see if there has been any change in physiology. The exercise program then is realigned successively to respond to the changes. In our experience thus far, symptoms disappear within several months for at least some of the patients," he said.
The specialists have worked with a small number of patients to date. They have included a UB soccer player who has returned to play and now is one of the team's leading scorers. Another young athlete was able to return to cross-country running and attend school full-time.
Willer, Leddy and other UB faculty members will present a half-day seminar on their treatment for concussion and post-concussion syndrome and the science behind it on Oct. 28 from 7:30 a.m. to noon in Butler Auditorium in Farber Hall on UB's South (Main Street) Campus.
The seminar, aimed primarily at physicians, also will be open to the public. Interested persons should contact the UB Office of Continuing Medical Education at 829-2378 or firstname.lastname@example.org for more information.
Lois Baker | EurekAlert!
Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University
The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Power and Electrical Engineering
05.12.2016 | Materials Sciences
05.12.2016 | Power and Electrical Engineering