For unknown reasons, 5-10 percent of people who experience a concussion have symptoms that persist beyond six weeks. These people are diagnosed with post-concussion syndrome (PCS). Previously there has been no treatment for the condition with proven success.
"The most common approach by physicians is to recommend no exercise and prescribe antidepressants," said Barry Willer, Ph.D., UB professor of psychiatry and rehabilitation sciences. Willer is lead author on the paper describing the new method, published in the September issue of Current Treatment Options in Neurology.
"Most people with PCS have symptoms of depression," said Willer, "so anti-depressant treatment makes sense. However, antidepressants do little more than relieve some of the depression symptoms. We were interested in a treatment that didn't just treat the symptoms, but actually improved the patient's brain function."
The researchers call their new treatment "regulated exercise." The approach consists of determining the ideal exercise program for each athlete based on a number of individual physiological indicators at baseline.
Patients are tested every two to three weeks with specialized equipment at the sports medicine clinic to determine their progress, and a new program is developed based on those results.
Willer and co-author John Leddy, M.D., clinical associate professor of orthopaedics and rehabilitation sciences, indicated it is too early to call the treatment a cure, but they are optimistic about the results so far.
The researchers described the treatment method in mid-September at the 2006 Brain Injury Conference of the Americas in Miami, where the response was very favorable, according to Willer.
"Professionals at the meeting were delighted that our approach to treatment of post-concussion syndrome doesn't involve any medications and is very cost-efficient. We were surprised to learn that we are among only a few investigators interested in people with symptoms that won't go away.
"There is no other known treatment specifically for PCS, which we define as persistent symptoms of concussion past the time they should have cleared, usually around three weeks," said Willer. "As far as we can determine, there is only one other group in North America that is using regulated exercise as part of the treatment for PCS."
Willer and Leddy have used regulated exercise successfully with people who were as much as six months post-concussion. Their regimen is based on the hypothesis that the regulatory system responsible for maintaining cerebral blood flow, which may be dysfunctional in people with a concussion, can be restored to normal by controlled, graded symptom-free exercise.
"The treatment program is well tolerated by patients" Willer said. "Just being able to exercise often reduces the depressive symptoms. But it's imperative that the patient not go beyond the exercise limits.
"After the first three weeks of regulated exercise, we reassess the patient to see if there has been any change in physiology. The exercise program then is realigned successively to respond to the changes. In our experience thus far, symptoms disappear within several months for at least some of the patients," he said.
The specialists have worked with a small number of patients to date. They have included a UB soccer player who has returned to play and now is one of the team's leading scorers. Another young athlete was able to return to cross-country running and attend school full-time.
Willer, Leddy and other UB faculty members will present a half-day seminar on their treatment for concussion and post-concussion syndrome and the science behind it on Oct. 28 from 7:30 a.m. to noon in Butler Auditorium in Farber Hall on UB's South (Main Street) Campus.
The seminar, aimed primarily at physicians, also will be open to the public. Interested persons should contact the UB Office of Continuing Medical Education at 829-2378 or firstname.lastname@example.org for more information.
Lois Baker | EurekAlert!
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
19.07.2017 | Event News
12.07.2017 | Event News
12.07.2017 | Event News
20.07.2017 | Information Technology
20.07.2017 | Materials Sciences
20.07.2017 | Physics and Astronomy