This new method, developed by a team of researchers led by biomaterials and drug delivery expert Dr John Tsibouklis at the University of Portsmouth, uses biodegradable polymer nanoparticles to administer drugs to the eye.
Nanoparticles are microscopic particles measured in nanometres (nm). These particles are so small that an ant, for example, measures millions of nanometers across.
Dr Tsibouklis said biodegradable polymers can be combined with drugs in such a way that the drug is released into the eye in a very careful and controlled manner.
The drug would have to be placed into the eye just once.
'The drug's release can be timed so it is constant, cyclic or triggered by an environmental or chemical signal, and the drug delivering polymer can be broken down naturally by the body when it is no longer needed,' Dr Tsibouklis said.
People with eye conditions who use eye drops regularly would benefit from the biodegradable polymer drug delivery method.
Eye drops have many disadvantages – two main ones being the need to administer drops regularly and low ocular bioavailability (too little of the drug is getting to areas of the eye most in need).
The common alternative option to eye drops, ophthalmic inserts, achieve sustained drug delivery but suffer from limitations also – they are difficult to insert, easy to misapply, and are expensive to manufacture.
Dr Tsibouklis is a reader in polymer science at the University of Portsmouth’s School of Pharmacy and Biomedical Sciences.
Dr Tsibouklis, and colleagues Dr Eugen Barbu, Dr Tom Nevell and Dr Liliana Verestiuc describe the new drug delivery systems in a paper, titled ‘Polymeric materials for ophthalmic drug delivery: trends and perspectives', published in the Journal of Materials Chemistry.
He said that the new drug delivery systems hold significant promise for the pharmaceutical industry.
Rajiv Maharaj | alfa
PET imaging tracks Zika virus infection, disease progression in mouse model
20.09.2017 | US Army Medical Research Institute of Infectious Diseases
'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
20.09.2017 | Life Sciences
20.09.2017 | Power and Electrical Engineering
20.09.2017 | Physics and Astronomy