Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Hormones could be prescription for living longer

Findings of studies presented at International Congress of Neuroendocrinology June 19-22

What's the secret to living longer? The answer to this age-old question might be found through research looking at neuroendocrine changes throughout the lifespan.

Reporting at the 6th International Congress of Neuroendocrinology (ICN 2006) in Pittsburgh, Polish researchers who studied women aged 20 to 102 suggest a small protein derived from fat tissue may be an important determinant of longevity. Other research indicates boosting growth hormone may allow the elderly to live independently longer. ICN 2006 takes place June 19 – 22 at the David L. Lawrence Convention Center in downtown Pittsburgh.

Summaries of these studies' findings follow:

Can stimulating growth hormone delay the physiological effects of aging?
Boosting production of growth hormone may extend the time that elderly men and women can live independently, suggests a study of an investigational oral medication led by George R. Merriam, M.D., professor of medicine at the University of Washington/VA Puget Sound Health Care System, and colleagues.

Aging is characterized by a progressive decline in muscle mass, strength and exercise capacity, often leading to frailty and the inability for living independently. Since growth hormone (GH) secretion also declines with age and many age-related changes resemble those seen in GH deficiency, the researchers are investigating the potential physical and endocrine effects of stimulating GH in older adults.

In this controlled trial involving 395 men and women aged 65 to 84 with mild limitations in their physical functioning, participants received either placebo or various oral doses of the growth hormone stimulator (GHS) capromorelin, an investigational medication discovered and developed by Pfizer Global Research and Development. Compared to placebo, GHS at any dose prompted an acute GH peak and an increase in overnight GH secretion – increases that were sustained throughout a 12-month treatment period. The GHS treatment also was associated with a 1.4 Kg increase in lean body (muscle) mass and an improvement in tandem (heel-to-toe) walking at 6 months and in stair climbing at 12 months.

Hormone may hold clue to longevity

A protein derived from fat tissue may be an important determinant of longevity, suggests a study of 133 women, including 25 aged 100 to 102, whom researchers found had notably higher levels of adiponectin circulating in their blood. Adiponectin is a peptide that has anti-inflammatory properties, helps keep vessels clear of fatty deposits and plays an important role in metabolism, particularly of lipids and glucose. Insufficient levels of adiponectin are thought to contribute to obesity, insulin resistance, diabetes or the formation of lipid deposits in the arteries, collectively known as symptoms of metabolic syndrome.

The study, which was conducted by Agnieszka Baranowska-Bik, M.D., and colleagues from the Medical Centre of Postgraduate Education, Warsaw, Poland, looked at blood plasma concentrations of adiponectin in four groups of women: the 25 centenarians, 26 women aged 64 to 67, 45 between the ages of 20 and 43, and 37 obese women aged 26 to 54. Compared to the other groups, the oldest old had significantly higher concentrations of adiponectin as well as much lower levels of both leptin and insulin. Moreover, the oldest-old women scored better with respect to insulin resistance and total cholesterol. Compared to the obese women, who, as expected, had more evidence of metabolic disturbances, the centenarians had significantly fewer signs of hypertension and other symptoms characteristic of metabolic syndrome. Dr. Baranowska-Bik stops short of calling adiponectin the fountain of youth, but the results of this study, she argues, provide evidence that adiponectin may play an important role in longevity.

Held in a different part of the world every four years under the auspices of the International Neuroendocrine Federation, this year's congress – Bridging Neuroscience and Endocrinology – is being sponsored by the American Neuroendocrine Society and the University of Pittsburgh School of Medicine. The first full day of the program, June 20, is being held in conjunction with the 10th Annual Meeting of the Society for Behavioral Neuroendocrinology.

Lisa Rossi | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Enormous dome in central Andes driven by huge magma body beneath it

25.10.2016 | Earth Sciences

First time-lapse footage of cell activity during limb regeneration

25.10.2016 | Life Sciences

Deep down fracking wells, microbial communities thrive

25.10.2016 | Earth Sciences

More VideoLinks >>>