Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Zinc Supplements Safe for HIV-Infected Children

28.11.2005


Supplements Reduce Frequency of Diarrhea Without Adverse Impact on Viral Load



Zinc-deficient children living in communities where they do not receive adequate amounts of zinc from their diet should be given supplements, even if they are HIV-infected, according to researchers from the Johns Hopkins Bloomberg School of Public Health and other institutions. Previously, it was not known if zinc would speed up HIV disease progression in children by increasing their viral load. Zinc supplementation is known to decrease the frequency of diarrhea and pneumonia in uninfected children. The study is published in the November 26, 2005, issue of The Lancet.

“We set out to look at the safety and impact of zinc supplements in children with HIV. Not only did we learn that zinc is safe for these children, but we also realized that this may be a low-cost intervention to reduce morbidity in HIV-infected children who don’t have access to antiretroviral therapy or are not eligible for treatment,” said William J. Moss, MD, MPH, senior author of the study and an assistant professor in the Bloomberg School of Public Health’s Department of Epidemiology.


The researchers completed a randomized, double-bind, placebo-controlled trial of zinc supplementation at an urban hospital in Pietermaritzburg, South Africa. The 96 children in the study were cared for on a monthly outpatient basis by a team of medical doctors and nurses. Parents were taught how and when to give the 10-mg zinc or placebo tablets to their child every day for six months. The children were seen at the hospital every two weeks for the first month, monthly for five months and, as a final visit, nine months after zinc or placebo supplementation began. At each follow-up visit, parents were asked about illnesses since the last visit. In addition, HIV-1 RNA in plasma and CD4+ T lymphocyte cell counts were measured one month before the study, at the first study visit and three, six and nine months after the start of supplementation.

The study authors found no increase in plasma HIV-1 viral load measurements in the children receiving zinc, meaning that zinc supplementation is safe for HIV-infected children. The CD4+ T lymphocytes and hemoglobin concentrations also were similar between the two study groups. Importantly, HIV-infected children who received zinc supplementation were less likely to get watery diarrhea.

“Programs to increase zinc supplementation in populations with a high prevalence of HIV infection can and should be implemented, and can be done so now that we know zinc does not have an adverse effect on HIV replication. Also, in light of the fact that zinc is known to reduce episodes of diarrhea and pneumonia, zinc supplementation should be used as an adjunct therapy for children with HIV infection,” said Moss.

The study was funded by the Johns Hopkins Family Health and Child Survival Cooperative Agreement with the Office of Health, Infectious Diseases and Nutrition Global Health Bureau at the U.S. Agency for International Development.

Robert E. Black, MD, MPH, chair of the Bloomberg School of Public Health’s Department of International Health, co-authored the study. Additional co-authors are Raziya Bobat, Hoosen Coovadia, Cindy Stephen, Kimesh L. Naidoo and Neil McKerrow.

Public Affairs media contacts for the Johns Hopkins Bloomberg School of Public Health: Kenna Lowe or Tim Parsons at 410-955-6878 or paffairs@jhsph.edu.

Kenna Lowe | EurekAlert!
Further information:
http://www.jhsph.edu

More articles from Health and Medicine:

nachricht Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>