Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gaps In Intestinal Barrier Could Cause Crohn’s Disease

16.09.2005


Scientists at the University of Liverpool believe gaps in the intestinal barrier could be a cause of inflammatory diseases of the gut such as Crohn’s Disease.



Their research, led by Professor Alastair Watson in the University’s Faculty of Medicine, could have important implications for the treatment of patients with diseases like Crohn’s – an inflammatory bowel disorder that causes severe ulceration in the intestine, leading to pain, bleeding and diarrhoea.

Professor Watson’s research has concentrated on the renewal of epithelial cells in the lining of the bowel and the ‘gaps’ in the lining that the process leaves behind.


The human bowel is lined with millions of projections called villi which increase the surface area of the intestine to allow for the efficient absorption of nutrients. The villi are covered in epithelial cells which are constantly renewed – around a thousand billion cells are shed from the top of the villi every day.

Professor Watson and his team found that this renewal process leaves ‘gaps’ in the lining of the bowel which, in healthy tissue, are immediately filled with a glue-like substance that plugs the gaps. The research team, discovering these gaps for the first time, found that around 3% of the bowel’s surface area is covered in this substance. It was previously assumed that the lining of the intestine was a continuous sheet of cells.

Professor Watson said: “We suspect that patients with inflammatory disease may not have the same ability to plug the gaps left by the cell renewal process – meaning that bacteria can seep through the lining of the intestine. Understanding this cell shedding process may lead to new treatments for inflammatory bowel disease.”

He added: “Our research may also explain the development of colon cancer which we believe may be down to a failure in the renewal process of epithelial cells. If they don’t renew but amass on the wall of the gut, they may develop into a cancer – it’s an area we’ll be concentrating on in the next stage of our study.”

The research, published in Gastroenterology, was carried out in collaboration with the University of Cincinnati.

Kate Spark | alfa
Further information:
http://www.liv.ac.uk

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>