During the last decade, cardiac resynchronization, as adjunctive therapy for patients with severe chronic heart failure has been the subject of many clinical trials. From its inception, although the idea of resynchronization had numerous supporters, chiefly those involved in pacing, while there were also a hardly insignificant number of skeptics.
The first encouraging results of cardiac resynchronization therapy (CRT) application were supported in studies that evaluated the hemodynamic benefits. A number of studies followed which examined results in exercise tolerance, quality of life and mortality. These study results showed that in a specific subgroup of patients with heart failure, CRT is an efficacious and beneficial therapy. However, these studies had weak points, mainly perhaps that they were not blinded. Thus, the benefits may be partly due to the closer monitoring of patients with the device. Additionally, a number of issues remain controversial, including the role of CRT in heart failure patients with narrow QRS, in patients with atrial fibrillation or right ventricular failure, as well as the ideal method of patient selection. The latter is particularly significant, as the cost of the therapy is quite high. Although the QRS duration was one of the inclusion criteria in most of the studies, the evidence suggests that inordinate contraction of the left ventricle is an essential for a favourable response. Therefore, for the moment, the progress from study results to clinical practice will have to be undertaken very carefully, to ensure that the patient will indeed benefit.
Gina Dellios | alfa
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering