During the last decade, cardiac resynchronization, as adjunctive therapy for patients with severe chronic heart failure has been the subject of many clinical trials. From its inception, although the idea of resynchronization had numerous supporters, chiefly those involved in pacing, while there were also a hardly insignificant number of skeptics.
The first encouraging results of cardiac resynchronization therapy (CRT) application were supported in studies that evaluated the hemodynamic benefits. A number of studies followed which examined results in exercise tolerance, quality of life and mortality. These study results showed that in a specific subgroup of patients with heart failure, CRT is an efficacious and beneficial therapy. However, these studies had weak points, mainly perhaps that they were not blinded. Thus, the benefits may be partly due to the closer monitoring of patients with the device. Additionally, a number of issues remain controversial, including the role of CRT in heart failure patients with narrow QRS, in patients with atrial fibrillation or right ventricular failure, as well as the ideal method of patient selection. The latter is particularly significant, as the cost of the therapy is quite high. Although the QRS duration was one of the inclusion criteria in most of the studies, the evidence suggests that inordinate contraction of the left ventricle is an essential for a favourable response. Therefore, for the moment, the progress from study results to clinical practice will have to be undertaken very carefully, to ensure that the patient will indeed benefit.
Gina Dellios | alfa
Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center
Study advances gene therapy for glaucoma
17.01.2018 | University of Wisconsin-Madison
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Life Sciences
18.01.2018 | Life Sciences
18.01.2018 | Earth Sciences