Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Two proteins for the diagnosis of lung diseases

01.09.2005


Immunohistochemical analysis combined with fibronectin and tenascin enables the diagnosis of fibroproliferative lung diseases to be carried out with greater reliability. Fibroproliferative lung disease is a lung function pathology covering some 200 diseases, amongst the most common being pulmonary fibrosis. These results were provided by Ana Echegoyen Silanes when she recently defended her PhD thesis at the Public University of Navarra.



200 different diseases

Lung function pathology takes in some 200 diseases which have much radiological and pathological data in common, and which can greatly shorten the life of the patient, the last resort being a lung transplant. Amongst these diseases, the most common are the interstitial pneumonias, more popularly known as pulmonary fibrosis.


A histological characteristic common to fibroproliferative alterations, states Ana Echegoyen, is the structural remodelling of the lung due to the uncontrolled deposition of collagen tissue at the lung interstices thus leading to pulmonary fibrosis. This fibrosis may be produced by two different mechanisms, interstitial fibrosis and intra-alveolar fibrosis, the latter being key in the structural remodelling of the lung.

The study was then based on two, non-collagenous proteins from the extra-cellular matrix of the pulmonary interstices, fibronectin and tenascin in different fibroproliferative processes of alveolar damage.

More reliable diagnoses

So, fibronectin is a protein from the extra-cellular matrix present in healthy pulmonary interstices the expression of which augments with both acute as well as chronic pulmonary damage and, together with collagen, is an essential constituent of stable fibrous tissue in chronic lung damage.

Tenascin is a protein of the extra-cellular matrix absent in healthy lungs which appears in the very initial stages of pulmonary aggression, maintaining its presence during the process of fibrogenesis and decreasing when the tissue fibrosis is already established. This pattern of expression suggests that tenascin is a regulatory, non-structural protein of the acute stage that participates in the tissue structural remodelling.

Immunohistochemical analysis combined with fibronectin and tenascin enables the diagnosis of the type of fibroproliferative lung diseases to be carried out with greater reliability. For example, the detection of tenascin indicates the lesion is at an active stage and that the response to treatment of the condition could be more effective than if it were not present, thus indicating chronification. This knowledge is important in terms of prognosis and therapy given that, with functional lung pathology, diagnosis - usually based on small tissue samples - is sometimes complicated. This is because we as pathologists see alterations in shape and structure, changes that have to be complemented with radiological findings and clinical history. Thus, the protocolising of techniques that enable the carrying out of histopathological diagnoses with enhanced reliability is eminently positive.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>