Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Two proteins for the diagnosis of lung diseases

01.09.2005


Immunohistochemical analysis combined with fibronectin and tenascin enables the diagnosis of fibroproliferative lung diseases to be carried out with greater reliability. Fibroproliferative lung disease is a lung function pathology covering some 200 diseases, amongst the most common being pulmonary fibrosis. These results were provided by Ana Echegoyen Silanes when she recently defended her PhD thesis at the Public University of Navarra.



200 different diseases

Lung function pathology takes in some 200 diseases which have much radiological and pathological data in common, and which can greatly shorten the life of the patient, the last resort being a lung transplant. Amongst these diseases, the most common are the interstitial pneumonias, more popularly known as pulmonary fibrosis.


A histological characteristic common to fibroproliferative alterations, states Ana Echegoyen, is the structural remodelling of the lung due to the uncontrolled deposition of collagen tissue at the lung interstices thus leading to pulmonary fibrosis. This fibrosis may be produced by two different mechanisms, interstitial fibrosis and intra-alveolar fibrosis, the latter being key in the structural remodelling of the lung.

The study was then based on two, non-collagenous proteins from the extra-cellular matrix of the pulmonary interstices, fibronectin and tenascin in different fibroproliferative processes of alveolar damage.

More reliable diagnoses

So, fibronectin is a protein from the extra-cellular matrix present in healthy pulmonary interstices the expression of which augments with both acute as well as chronic pulmonary damage and, together with collagen, is an essential constituent of stable fibrous tissue in chronic lung damage.

Tenascin is a protein of the extra-cellular matrix absent in healthy lungs which appears in the very initial stages of pulmonary aggression, maintaining its presence during the process of fibrogenesis and decreasing when the tissue fibrosis is already established. This pattern of expression suggests that tenascin is a regulatory, non-structural protein of the acute stage that participates in the tissue structural remodelling.

Immunohistochemical analysis combined with fibronectin and tenascin enables the diagnosis of the type of fibroproliferative lung diseases to be carried out with greater reliability. For example, the detection of tenascin indicates the lesion is at an active stage and that the response to treatment of the condition could be more effective than if it were not present, thus indicating chronification. This knowledge is important in terms of prognosis and therapy given that, with functional lung pathology, diagnosis - usually based on small tissue samples - is sometimes complicated. This is because we as pathologists see alterations in shape and structure, changes that have to be complemented with radiological findings and clinical history. Thus, the protocolising of techniques that enable the carrying out of histopathological diagnoses with enhanced reliability is eminently positive.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>