A collaboration between Johns Hopkins and Massachusetts Institute of Technology scientists has mathematically demonstrated that a national matching program for kidney paired donation, also called paired kidney exchange, would ensure the best possible kidney for the greatest number of recipients who have incompatible donors. Kidney paired donation (KPD) provides organs to patients who have a willing, designated donor who is not compatible. A kidney from such a donor is matched to -- and transplanted into -- the recipient of a second incompatible donor-patient pair, and vice versa. The transplants are performed simultaneously.
The researchers have developed an interactive Web site, www.OptimizedMatch.com, that provides more details and interactive demonstrations of the algorithm and its use in transplantation.
"Our findings demonstrate that a national pool of kidney donors and recipients, combined with new mathematical techniques for sorting through them to find the best possible organ matches, will not only allow more people to get the transplants they need, but will dramatically cut health care costs, reduce disruptive and unnecessary travel for patients, and insure that transplanted kidneys have the best possible chance of survival," said Dorry L. Segev, M.D., a surgeon at Johns Hopkins and lead author of a report published in the April 20, 2005, issue of the Journal of the American Medical Association.
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