Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lung cancer vaccine trial continues at UK’s Markey Cancer Center

06.04.2005


Two University of Kentucky researchers continue their work with a vaccine to prevent lung cancer recurrences in patients following primary treatment of the disease.



Vaccines are being developed with the hope of reducing the unacceptably high rates of recurrence and disease progression seen in the treated lung cancer population. The cancer vaccine program is now enrolling a second cohort of subjects to study the effects of the vaccine in lung cancer patients. The vaccine is delivered following conventional treatment with surgery, radiation therapy or chemotherapy and the patients evaluated for immune responses that could indicate clinical benefit.

Edward A. Hirschowitz, M.D., Associate professor of medicine, and John Yannelli, Ph.D., Associate professor of Microbiology and Immunology, both in the UK College of Medicine, are using white blood cells from the patients’ blood to make the vaccine. They then administer the vaccine to the patient which allows the patient’s immune system to recognize and destroy tumor cells that can lead to recurrences after cancer treatment.


"This trial is important in the fight against lung cancer because additional medical therapies are not generally recommended until recurrences are seen," said Hirschowitz. "We are using the window between definitive medical or surgical therapy and lung cancer recurrence to enhance the immune response to a cancer recurrence."

The vaccine in this study uses dendritic cells, the most potent immune inducing cells found in the human body. In the lab these cells can be grown in large numbers then programmed with tumor information that directs the immune system to recognize and kill tumor cells in the body.

"UK is in the forefront of cancer research and therapy with this study," said Yannelli. "Only in the past five years have scientists learned to grow these cells in large numbers and manipulate their biology in laboratory culture. As a result, we can experimentally culture these cells in the lab and inject patients with more of these potent cells to engineer immune responses to different diseases."

In the previous cohort the researchers had very positive biological results and patient outcomes. In this second group, the researchers hope to treat 30 new patients over a period of two years. Each patient receives two injections of the dendritic cells, one month apart. It takes seven days to make the vaccine. Following careful monitoring to insure the vaccine is safe, the antigen loaded dendritic cells are injected into the patient. The second dose is administered a month later.

Initially, the Kentucky Lung Cancer Tobacco Settlement Foundation gave the researchers $200,000 to start the project and an additional; $500,000 was secured from the Cancer Treatment Research Foundation. They have recently secured another grant for $700,000 to further their efforts.

Kentucky has the highest incidence of lung cancer in the country. "Kentucky has such a devastating problem, developing vaccines research here is really important. A seemingly endless stream of lung cancer patients seen in our clinics continually reinforces the importance of this research. " said Hirschowitz "UK is one of the prevailing lung cancer vaccine centers in the U.S."

Louise DuPont | EurekAlert!
Further information:
http://www.uky.edu

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>