Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Combined Treatment Approach Increases Survival In Prostate Cancer

05.04.2005


New study shows combination of radiotherapy and hormone therapy extends life expectancy.



Men with prostate cancer treated with the combined therapies had a significantly higher chance of living for more than 10 years than those on radiotherapy alone. This was one of the main results published today in the International Journal of Radiation Oncology, Biology and Physics (IJROBP) by the independent Radiation Oncology Group (RTOG).

Goserelin belongs to a class of drugs called Luteinizing Hormone-Releasing Hormone agonist (LHRHa). This therapeutic modality works by inhibiting the production of the male hormone, testosterone.


The research also showed that by treating men with goserelin and radiotherapy, the chances of preventing the disease from coming back were improved by 60 percent compared to men who only received radiotherapy.1

Another study published this month in the British Journal of Urology International (BJUi) confirmed that these benefits were not seen in all LHRHas. Experts examined all LHRHas medications, but goserelin has been proven to be the only LHRHa providing proven benefit in terms of delaying progression and improving survival.

Mr Amir Kaisary, Consultant Urologist, Royal Free Hospital, London believes the RTOG’s publication is a major step forward in increasing the amount of attention being given to prostate cancer, which has always struggled to achieve the levels of public awareness of some other cancers.

‘Studies, such as the one published today in the IJROBP, are proving that surgical castration and radiotherapy are not the only treatments available for men with prostate cancer. An increasing amount of evidence shows that hormonal therapy, used either alone or with radiotherapy, offers significant benefits for men with prostate cancer, when offered in the appropriate patients.’

The study published in the IJROBP observed nearly 1,000 men with locally advanced prostate cancer over a 10 year period. The aim of the research was to determine how effective goserelin was when used with radiotherapy to treat men with locally advanced prostate cancer. This group of prostate cancer patients is where the cancer is no longer contained within the prostate gland as at the early stages of the disease.

The Department of Health has recognised the benefits of hormonal therapies because of studies such as the one published in the IJROBP. It has issued guidelines supporting the treatment of men with locally advanced prostate cancer using radiotherapy and a hormonal therapy. Anti-androgens are another type of hormonal therapy which can also be used to treat locally advanced prostate cancer. Anti-androgens block the biochemical transformation of androgens (the main one is testosterone) to the active form which stimulate the growth of prostate cancer tumours. Anti-androgens are increasingly being used by clinicians because they do not affect men’s physical strength, sexual interest or increase the risk of bone fractures. These are side effects which are associated with LHRHa therapy.

It is important that men with prostate cancer, when possible, are fully informed about the different side effects and can discuss with their doctor which treatment is the most suitable for their lifestyle and individual needs.

Tara Breen | alfa
Further information:
http://www.hillandknowlton.com

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>