A therapeutic cancer vaccine being co-developed by the Ludwig Institute for Cancer Research (LICR) and the Australian biotechnology company CSL Limited successfully induced a comprehensive immune response in patients and appeared to delay cancer recurrence, according to a paper published today in the scientific journal, Proceedings of the National Academy of Sciences USA.
The study treated 46 patients, most with melanoma, with three monthly doses of the NY-ESO-1/ISCOMATRIXTM vaccine following surgical removal of the tumor. The vaccine combines a cancer-specific protein, the NY-ESO-1 antigen, with an immune stimulant, the ISCOMATRIXTM adjuvant, from CSL Ltd. In the study, some patients received different doses of the NY-ESO-1/ISCOMATRIXTM vaccine, some received the NY-ESO-1 protein without the ISCOMATRIXTM complex, and some received an inactive placebo. Detailed studies of the patients’ immune responses revealed that the NY-ESO-1/ISCOMATRIXTM vaccine, in contrast to vaccination with the placebo, induced the production of antibodies, and CD8 and CD4 T cells that target the NY-ESO-1 antigen. Vaccination with the NY-ESO-1 protein alone induced fewer responses than the NY-ESO-1/ISCOMATRIXTM vaccine.
“These results are very exciting,” says Dr. Jonathan Cebon, Head of the Joint Austin Health/Ludwig Institute Oncology Unit in Melbourne. “They show that it is possible to stimulate an integrated immune response that has the potential to attack cancer from a number of different angles. Being able to get antibodies, together with both types of T cells, gives us enormous confidence that we are heading in the right direction to develop a clinically effective therapy.”
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Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
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Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
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