Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein promotes cancer metastasis and survival

20.04.2004


A new study demonstrates that a protein called periostin promotes deadly spreading and late stage progression of colon cancer. The research results demonstrate that periostin promotes metastatic growth of colon cancer by activating signaling molecules that encourage cell survival and identify the protein as a potential therapeutic target for the control of colon cancer.



Colorectal cancer commonly metastasizes to the liver and is the second leading cause of death from cancer in the United States. As with most cancers, it is the metastasis and not the primary tumor that is responsible for cancer fatality. However, the complex mechanisms associated with tumor metastasis are not very well understood. Dr. Xiao-Fan Wang from Duke University Medical Center and colleagues searched for genes associated with metastatic tumors in samples from primary and metastatic colon cancers and found that periostin was highly expressed in metastatic tumors. When periostin was introduced into human colon cancer cells grown in the laboratory, the cells were much more likely to metastasize to the liver when subsequently introduced into mice. The researchers went on to show that the underlying molecular mechanism for periostin-mediated tumor metastasis is related to an increase in survival of cancer and blood vessel cells under stressful conditions.

The researchers conclude that periostin plays a critical role in the progression of colon cancers and may be involved in metastasis of other cancers as well. "Metastasis accounts for the majority of the mortality associated with colorectal cancer, making control of metastasis an attractive treatment goal," explains Dr. Wang. "Our findings identify periostin as a potent promoter of late stage tumor progression. It is likely that periostin and similar types of proteins enable tumor cells to thrive in distant organs and grow under conditions that normally would be inhospitable. Targeting these proteins may prove to be a highly effective strategy for preventing late-stage progression of deadly metastatic cancers."



Shideng Bao, Gaoliang Ouyang, Xuefang Bai, Zhi Huang, Chaoyu Ma, Ming Liu, Rong Shao, Ryan M. Anderson, Jeremy N. Rich, and Xiao-Fan Wang: "Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway"

Published in Cancer Cell, Volume 5, Number 4, April 2004.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>