A new study demonstrates that a protein called periostin promotes deadly spreading and late stage progression of colon cancer. The research results demonstrate that periostin promotes metastatic growth of colon cancer by activating signaling molecules that encourage cell survival and identify the protein as a potential therapeutic target for the control of colon cancer.
Colorectal cancer commonly metastasizes to the liver and is the second leading cause of death from cancer in the United States. As with most cancers, it is the metastasis and not the primary tumor that is responsible for cancer fatality. However, the complex mechanisms associated with tumor metastasis are not very well understood. Dr. Xiao-Fan Wang from Duke University Medical Center and colleagues searched for genes associated with metastatic tumors in samples from primary and metastatic colon cancers and found that periostin was highly expressed in metastatic tumors. When periostin was introduced into human colon cancer cells grown in the laboratory, the cells were much more likely to metastasize to the liver when subsequently introduced into mice. The researchers went on to show that the underlying molecular mechanism for periostin-mediated tumor metastasis is related to an increase in survival of cancer and blood vessel cells under stressful conditions.
The researchers conclude that periostin plays a critical role in the progression of colon cancers and may be involved in metastasis of other cancers as well. "Metastasis accounts for the majority of the mortality associated with colorectal cancer, making control of metastasis an attractive treatment goal," explains Dr. Wang. "Our findings identify periostin as a potent promoter of late stage tumor progression. It is likely that periostin and similar types of proteins enable tumor cells to thrive in distant organs and grow under conditions that normally would be inhospitable. Targeting these proteins may prove to be a highly effective strategy for preventing late-stage progression of deadly metastatic cancers."
Heidi Hardman | EurekAlert!
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences