Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Skin regeneration not isolated to epidermal stem cells


The outermost layer of the skin – the epidermis – is a rapidly renewing tissue and relies on the regenerative capacity of keratinocytes. Skin grafts using human cultured epidermal cells have been successful in treating patients with severe skin wounds. The notion that the ability to regenerate functional epidermal tissue is an exclusive property of epidermal stem cells is a general assumption in the stem cell biology field. In the February 2 issue of the Journal of Clinical Investigation, Pritinder Kaur and colleagues at the Peter MacCallum Cancer Centre, Australia, demonstrate that both epidermal stems cells and their early, differentiated progeny contribute to rapid epidermal regeneration.

The majority of proliferating epidermal cells, also known as transit-amplifying cells, at the inner-most layer of the skin have a finite life span and undergo rapid terminal differentiation. Therefore it is well accepted that the extensive regenerative capacity of the skin is most likely attributed to the activity of epidermal stem cells.

To determine the cells responsible for rapid epidermal regeneration, Kaur and colleagues separated epidermal stem cells from their progeny and assayed the ability of both cell types to regenerate epidermal tissue in both in vitro and in vivo settings. As expected, keratinocyte stem cells displayed robust regenerative capabilities, but unexpectedly, transit-amplifying cells and early differentiating cells, which are more committed progenitor cells, could also form a fully stratified epidermis under appropriate microenvironmental conditions. The authors also demonstrated that the regenerative capacity of these cell types could be enhanced by exposure to the protein laminin-10/11.

This work presents important new considerations for the expansion of keratinocyte progenitor cell populations for therapies that require large numbers of epidermal cells, such as those required for the treatment of severe wounds such as extensive burns. It may be possible to harness the vast proliferative potential of readily available and accessible keratinocyte progenitors of the skin for cellular therapies, thereby removing the need for difficult and limited stem cell selection.

TITLE: Extensive tissue-regenerative capacity of neonatal human keratinocyte stem cells and their progeny

Pritinder Kaur
Peter MacCallum Cancer Centre, Melbourne, Australia.
Phone: 61-3-9656-3714
Fax: 61-3-9656-3738

View the PDF of this article at:

Brooke Grindlinger | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>