Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hope For New Meningitis Vaccine

05.01.2004


Research performed by scientists at the School of Biomedical and Molecular Sciences, University of Surrey and the Health Protection Agency (Porton Down, Salisbury) provides hope for developing a new meningitis vaccine that will protect children against all groups of meningococcus.



Published in the journal, Infection and Immunity, the research found that meningococcus is responsible for epidemics of meningitis worldwide that kills thousands of children each year. Vaccines are available for the A and C groups, but no effective vaccine is currently available for B groups. There are about 1500 confirmed cases of group B meningitis in the UK each year, but the true incidence is likely to be nearer twice that number since many cases go unreported. About 10% of children who suffer meningococcal meningitis die of the disease and many of the survivors are left severely handicapped.

The Surrey researchers used genetic engineering technology to make a mutant group of the meningococcus that was incapable of causing disease in mice. The mutant was made in a C group of the meningococcus. However, mice that were inoculated with the mutant group developed antibodies that killed not only C groups but also B and A groups. It appears that, by inoculating with the disabled group, the mice have effectively been immunised against all groups.


The research suggests that it should be possible to develop a single vaccine to protect against all groups of the meningococcus. Such a vaccine could revolutionise meningitis vaccination around the world. The researchers are now analysing the immune response of the immunised mice to try and discover the identity of the targets that the mouse antibodies are hitting.

Although much work needs to be done, the research holds real promise that a new vaccine may be developed that will protect children against all groups of the meningococcus, both in the UK and around the world.

The research is supported by the Meningitis Trust.

Liezel Tipper | alfa
Further information:
http://www.surrey.ac.uk

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>