A new study shows that molecular analysis of a very small tissue sample can identify hidden melanoma metastases in lymph nodes. The presence of melanoma in the lymph nodes is the single most important factor in determining a patients prognosis and is a key factor in determining a patients course of treatment.
Published in the October 1 issue of the Journal of Clinical Oncology, the study is the first to use such a thin section of archival paraffin-embedded tissue and show that a specific set of molecular characteristics indicates the presence of melanoma in the lymph nodes – even among patients whose lymph nodes appear cancer-free using standard techniques. By using a small tissue section, pathologists spare more of the whole specimen, which is needed for additional pathology tests.
"Our findings show that by performing molecular analysis on a very small piece of tissue, we can quickly and accurately identify previously undetectable metastases, and provide a more accurate prognosis for patients," said Dr. Dave S.B. Hoon, director of the Department of Molecular Oncology at the John Wayne Cancer Institute in Santa Monica, California, and senior author of the study. "Providing a more accurate prognosis can inform decisions on when and how to treat patients, and could ultimately improve our ability to care for patients with melanoma."
Carrie Housman | EurekAlert!
Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena
Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
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