Post-operative chemotherapy in non-small cell lung cancer (NSCLC) looks like an attractive proposition to prevent the cancer recurring, said Professor Nick Thatcher, of the Christie Hospital, Manchester, UK at the ECCO-12 conference in Copenhagen today (Tuesday 23 September). But the recent IALT study, which is said to demonstrate a survival advantage for patients given adjuvant treatment, was statistically unreliable and needed to be taken in context, he said.
"A large body of evidence – 17 cisplatin trials as opposed to 1, the IALT study -demonstrated no survival advantage with the use of cisplatin-based adjuvant chemotherapy", said Professor Thatcher.
A meta-analysis of 14 trials of adjuvant (post resection cisplatin therapy) in NSCLC not only showed no survival benefit with chemotherapy, said Professor Thatcher, but with adjuvant radiotherapy (which was included in the IALT study) there was a survival detriment, 7% more people treated dying over 2 years. Three other more recent randomised cisplatin trials had also failed to show a survival benefit among patients receiving adjuvant chemotherapy in NSCLC, he said.
Mary Rice | EurekAlert!
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