Research by Johns Hopkins Kimmel Cancer Center specialists has uncovered a novel pathway in the origin of pancreatic cancers, one of the deadliest of malignancies. Their findings are reported in the June 23, 2003, issue of Cancer Cell.
Working with cancer cells from 55 patients, the Hopkins team found that a growth signal normally turned off in adult tissues is mistakenly turned back on after injury or inflammation of the pancreas. "We think reactivation may be a first step in initiating pancreatic cancer, well before the onset of any alterations to the pancreatic cells genetic material," says Steven D. Leach, M.D., Paul K. Neumann Professor in Pancreatic Cancer at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and director of the study.
The Notch pathway, when functioning normally, regulates embryonic development in a wide variety of organisms, ranging from fruit flies to humans. In adult tissues, the pathway becomes dormant as cells become differentiated to perform specialized functions. But, when the pancreas is injured or diseased, Notch signaling may be reactivated in the adult pancreas, resulting in conversion of adult pancreas cells to cells similar to those seen in embryonic pancreas. These primitive cells accumulate in the epithelium, or lining, of the pancreas, setting the stage for the additional genetic changes that lead to cancer. "Using drugs to deactivate the Notch pathway could prevent these cancer-causing events from occurring," says Leach.
Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin
One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
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