Researchers have identified a mechanism by which the eight amino acid peptide NAP, an active fragment of a neuroprotective brain protein, protects against alcohol-induced embryo toxicity and growth retardation in mice. Their findings bring alcohol researchers a critical step closer to developing pharmacologic agents to prevent alcohol-induced fetal damage. The study, funded by the National Institutes of Healths National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Child Health and Human Development (NICHD), and the Medical Research Service, Department of Veterans Affairs, appears in the current issue of the Proceedings of the National Academy of Sciences.*
The researchers produced NAP derivatives with specific substitutions and screened the compounds in cultured rat neurons for their protection against cell toxins and in whole mouse embryos for their protection against alcohol. By manipulating NAPs structure and thereby altering its activity, the researchers were able to examine the ability of the different NAP derivatives to block alcohol inhibition of the L1 cell adhesion molecule. Their results indicate that NAP protects mouse embryos from alcohol toxicity by blocking alcohol effects on L1 rather than by its broad neuroprotective actions.
"This elegant study demonstrates that the protective effect of NAP against alcohol damage differs from that of NAP against neurotoxins, said Ting-Kai Li, M.D., Director, National Institute on Alcohol Abuse and Alcoholism. "Ethanol inhibition of L1 is now strongly implicated in the pathogenesis of fetal alcohol damage and a foremost target of medication development."
Ann Bradley | EurekAlert!
PET imaging tracks Zika virus infection, disease progression in mouse model
20.09.2017 | US Army Medical Research Institute of Infectious Diseases
'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
20.09.2017 | Life Sciences
20.09.2017 | Power and Electrical Engineering
20.09.2017 | Physics and Astronomy