Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mouse study identifies protective mechanism against alcohol-induced embryo toxicity

10.06.2003


Researchers have identified a mechanism by which the eight amino acid peptide NAP, an active fragment of a neuroprotective brain protein, protects against alcohol-induced embryo toxicity and growth retardation in mice. Their findings bring alcohol researchers a critical step closer to developing pharmacologic agents to prevent alcohol-induced fetal damage. The study, funded by the National Institutes of Health’s National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Child Health and Human Development (NICHD), and the Medical Research Service, Department of Veterans Affairs, appears in the current issue of the Proceedings of the National Academy of Sciences.*



The researchers produced NAP derivatives with specific substitutions and screened the compounds in cultured rat neurons for their protection against cell toxins and in whole mouse embryos for their protection against alcohol. By manipulating NAP’s structure and thereby altering its activity, the researchers were able to examine the ability of the different NAP derivatives to block alcohol inhibition of the L1 cell adhesion molecule. Their results indicate that NAP protects mouse embryos from alcohol toxicity by blocking alcohol effects on L1 rather than by its broad neuroprotective actions.

"This elegant study demonstrates that the protective effect of NAP against alcohol damage differs from that of NAP against neurotoxins, said Ting-Kai Li, M.D., Director, National Institute on Alcohol Abuse and Alcoholism. "Ethanol inhibition of L1 is now strongly implicated in the pathogenesis of fetal alcohol damage and a foremost target of medication development."


Michael Charness, M.D., of the Veterans Administration Boston Healthcare System and Department of Neurology, Harvard Medical School, headed up the study, with colleagues from the NICHD and the University of North Carolina Bowles Center for Alcohol Studies.

NAP, technically known as NAPVSIPQ, is known to be protective in minute concentrations against a wide array of neural insults and recently was shown to prevent alcohol-induced fetal wastage and growth deficits in mice. In September 2002, Dr. Charness with other colleagues reported that NAP also blocks alcohol’s inhibitory effects on cell-cell aggregation (the clustering of fetal cells destined to become the brain and nervous system) as mediated by the cell adhesion molecule known as L1. Whether NAP’s broader neuroprotective action or its specific effects on cell adhesion were responsible for preventing fetal damage remained to be determined.

The leading preventable cause of mental retardation in the United States, fetal alcohol syndrome affects about 1 in 1,000 U.S. infants and about 6 percent of children born to alcoholic women. Fetal alcohol syndrome imposes lifetime economic costs estimated at $1.8 million per child in health care and indirect costs such as lost productivity.

Ann Bradley | EurekAlert!
Further information:
http://www.niaaa.nih.gov/

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>