Prolactin, a naturally occurring peptide hormone needed for milk production following pregnancy, has been found to play a major role in the development and spread of breast cancer. More recently, Dr. Charles Clevenger, the same researcher who first demonstrated the scope and mechanism of prolactins role in cancer, has discovered that prolactin functions directly inside the cell, not merely by sending signals across the cell membrane as had been assumed for it and all other peptide hormones.
Dr. Clevenger also has discovered how prolactin is able to travel across the cell membrane and directly into the DNA machinery of the cell. These findings suggest a pathway through which new therapies could block the growth and spread of breast cancer -- and offer a new paradigm for how other hormones function, not just in breast cancer but in a number of other diseases.
The University of Pennsylvania researcher describes his research at the Experimental Biology 2003 meetings in San Diego. He will be honored by the American Society of Investigative Pathology, at the EB 2003 meeting, with the Pfizer Outstanding Investigator Award. The award honors a decade of steady unraveling, by Dr. Clevenger, of how prolactin works in breast cancer, including this most recent discovery.
Sarah Goodwin | EurekAlert!
Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku
Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy