Prolactin, a naturally occurring peptide hormone needed for milk production following pregnancy, has been found to play a major role in the development and spread of breast cancer. More recently, Dr. Charles Clevenger, the same researcher who first demonstrated the scope and mechanism of prolactins role in cancer, has discovered that prolactin functions directly inside the cell, not merely by sending signals across the cell membrane as had been assumed for it and all other peptide hormones.
Dr. Clevenger also has discovered how prolactin is able to travel across the cell membrane and directly into the DNA machinery of the cell. These findings suggest a pathway through which new therapies could block the growth and spread of breast cancer -- and offer a new paradigm for how other hormones function, not just in breast cancer but in a number of other diseases.
The University of Pennsylvania researcher describes his research at the Experimental Biology 2003 meetings in San Diego. He will be honored by the American Society of Investigative Pathology, at the EB 2003 meeting, with the Pfizer Outstanding Investigator Award. The award honors a decade of steady unraveling, by Dr. Clevenger, of how prolactin works in breast cancer, including this most recent discovery.
Sarah Goodwin | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy