Prolactin, a naturally occurring peptide hormone needed for milk production following pregnancy, has been found to play a major role in the development and spread of breast cancer. More recently, Dr. Charles Clevenger, the same researcher who first demonstrated the scope and mechanism of prolactins role in cancer, has discovered that prolactin functions directly inside the cell, not merely by sending signals across the cell membrane as had been assumed for it and all other peptide hormones.
Dr. Clevenger also has discovered how prolactin is able to travel across the cell membrane and directly into the DNA machinery of the cell. These findings suggest a pathway through which new therapies could block the growth and spread of breast cancer -- and offer a new paradigm for how other hormones function, not just in breast cancer but in a number of other diseases.
The University of Pennsylvania researcher describes his research at the Experimental Biology 2003 meetings in San Diego. He will be honored by the American Society of Investigative Pathology, at the EB 2003 meeting, with the Pfizer Outstanding Investigator Award. The award honors a decade of steady unraveling, by Dr. Clevenger, of how prolactin works in breast cancer, including this most recent discovery.
Sarah Goodwin | EurekAlert!
Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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