Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Defective genes increase breast cancer risk in young women to a greater extent than previously estimated

02.04.2003


A joint study between St Mary’s Hospital, the Paterson Institute, Christie Hospital, The University of Manchester, Guys Hospital in London, and Cambridge University researching breast cancer has found that women with defects in certain genes have a higher chance of developing breast cancer when they are young than previous estimates. The report calls for more family history information to be taken from young women with breast cancer.



Breast cancer affects one woman in 10 to 12 in the UK, and about 5% of cases are due to strong hereditary factors. It was previously estimated that defects in one of a few genes were responsible for around 50% of the inherited breast cancers. The study says that mutations in one of three genes - BRCA1, BRCA2 and TP53 – could be responsible for about 60% of the inherited breast cancers.

It is the first study of it’s kind to look at the presence of all mutations in these three genes in women, and in such a large number of young women.


Ninety-nine women with breast cancer under the age of 30 took part in the study. One-third of the young women had a family history of breast cancer. Experts looked at the DNA of all the women to see whether they had mutations in one of three genes associated with breast cancer - BRCA1, BRCA2 and TP53. Forty seven per cent of the women with a family history of breast cancer had a mutation in one of these three genes. Of the women with no family history, one had a BRCA2 mutation (1.6%) and two a TP53 mutation (3%). This clearly shows that a family history of cancer indicates that the patient is likely to have a defective gene.

Strikingly, in fifty five per cent of cases where the women had a family history, there was no description of such a history in the hospital notes. This study stresses the need to make sure that details of other cancers in the family are recorded.

Professor Gareth Evans, Consultant Geneticist at St Mary’s Hospital and the Christie Hospital in Manchester said: “Among young breast cancer patients the recording of family history is frequently inadequate. This study demonstrates the importance of accurately recording a family history including the paternal side.

“We are recommending that all breast cancer notes carry a section on family history that has to be completed. With better recording of we can predict the majority young women carrying mutation genes, and as a result can alter how we clinically manage these patients. For example women with TP53 mutations are highly radiation-sensitive. As a consequence their diagnoses and treatment may be changed.

"As well as being able to identify and monitor susceptible women, it’s important for us to educate and counsel women about genetic information and cancer risk."

Genes are important in regulating growth and repairing the DNA in cells. A faulty gene can deprive a cell of the crucial brakes needed to stop the controlled division typically found in cancer. Women with the gene can already be given more frequent mammograms to check for breast cancer. They may even have healthy tissue removed as a preventative measure. It is important to stress that not every woman with an altered gene will develop breast cancer.”

Jo Grady | alfa
Further information:
http://news.man.ac.uk

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>