Researchers at the University of Pittsburgh Cancer Institute (UPCI), in collaboration with Johns Hopkins University School of Medicine have found that a recently discovered gene plays an essential role in mediating apoptosis, or cell death, in colorectal cancer cells. The results are published in the Feb. 18 issue of Proceedings of the National Academy of Sciences.
The gene, PUMA, or p53 up-regulated modulator of apoptosis, is controlled by p53 – a tumor-suppressing gene that prevents normal cells from turning into life-threatening tumor cells. Previous research has determined that damage to p53 is fundamental to the development of a vast majority of cancers, and inactivation of the growth-controlling function of p53 is critical to the growth and spread of most cancers.
The leading investigators of the study, Lin Zhang, Ph.D., assistant professor of pharmacology, University of Pittsburgh and Jian Yu, Ph.D., assistant professor of pathology, University of Pittsburgh, performed several gene targeting experiments involving PUMA and found that if the gene is deleted in colorectal cancer cells, cell death is prevented. These findings build on previous findings published in 2001 in Molecular Cell, where the same research team identified PUMA as a novel gene that when expressed, resulted in rapid and profound apoptosis.
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High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons
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The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
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