When developing a treatment plan for cervical cancer, it is important to be able to determine a patients prognosis, ideally at the time of diagnosis. Existing methods to arrive at a prognosis can be time consuming, inaccurate and may require specialized software. Therefore, doctors from the Washington University School of Medicine developed – and validated – an accurate, reproducible and quick prognostic system.
The researchers created a grading scale to use in conjunction with a simple visual analysis of 18F-FDG PET scans. The grading system considered the size and shape of the primary tumor, as well as the heterogeneity of 18F-FDG uptake and presence of lymph nodes. A cutoff value was established to separate the women with "good" and "bad" prognoses, and Kaplan-Meier analysis provided a guideline both for progression-free survival and for overall survival. Researchers also examined whether knowledge about the presence of lymph notes impacted the efficacy of the system.
The retrospective study was conducted using data from 47 patients. Three independent observers, who had no knowledge of the patients, evaluated and graded the PET scans. The close scores and survival prognoses of the three observers demonstrated the reproducibility of the test. A comparison of the observers projected outcomes and the actual outcomes verified the accuracy and the power of this visual analysis; for example, 80% of those women who were predicted to have a bad diagnosis did not survive while only 10% with a good prognosis died. The information about the presence of lymph nodes increased the accuracy only slightly compared to the analysis of tumor characteristics alone.
Kimberly A. Bennett | EurekAlert!
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
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Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
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