When developing a treatment plan for cervical cancer, it is important to be able to determine a patients prognosis, ideally at the time of diagnosis. Existing methods to arrive at a prognosis can be time consuming, inaccurate and may require specialized software. Therefore, doctors from the Washington University School of Medicine developed – and validated – an accurate, reproducible and quick prognostic system.
The researchers created a grading scale to use in conjunction with a simple visual analysis of 18F-FDG PET scans. The grading system considered the size and shape of the primary tumor, as well as the heterogeneity of 18F-FDG uptake and presence of lymph nodes. A cutoff value was established to separate the women with "good" and "bad" prognoses, and Kaplan-Meier analysis provided a guideline both for progression-free survival and for overall survival. Researchers also examined whether knowledge about the presence of lymph notes impacted the efficacy of the system.
The retrospective study was conducted using data from 47 patients. Three independent observers, who had no knowledge of the patients, evaluated and graded the PET scans. The close scores and survival prognoses of the three observers demonstrated the reproducibility of the test. A comparison of the observers projected outcomes and the actual outcomes verified the accuracy and the power of this visual analysis; for example, 80% of those women who were predicted to have a bad diagnosis did not survive while only 10% with a good prognosis died. The information about the presence of lymph nodes increased the accuracy only slightly compared to the analysis of tumor characteristics alone.
Kimberly A. Bennett | EurekAlert!
Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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