By redesigning the shell of Ebola, Purdue University researchers have transformed the feared virus into a benevolent workhorse for gene therapy – and as one of the first gene bearers that can be inhaled rather than injected, it might prove valuable in the fight against lung disease.
While replacing the infection-causing genes inside an ordinarily harmful retrovirus with helpful genetic material is a relatively common research practice, David Sanders and his colleagues have gone a step beyond this technique.
The group, which also includes Anthony Sanchez of the Centers for Disease Control and Purdue graduate student Scott Jeffers, has hit upon a way to simplify Ebolas outer shell as well, rendering it more easily produced in a laboratory and more effective at delivering genes to defective cells. Since unmodified Ebola enters through, and attacks, the lungs, defective lung cells could benefit most from therapy based on this discovery.
Chad Boutin | Purdue News
Dengue takes low and slow approach to replication
12.01.2018 | Duke University
Fast food makes the immune system more aggressive in the long term
12.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes. If the researchers blocked the corresponding molecules, the immune system was significantly less active. The study was conducted under the auspices of the German Center for Diabetes Research (DZD) and was published in the journal ‘Science Translational Medicine’.
Type 1 diabetes is the most common metabolic disease in childhood and adolescence. In this disease, the body's own immune system attacks and destroys the...
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15.01.2018 | Life Sciences
15.01.2018 | Life Sciences