Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer pain control possible with gene therapy

15.10.2002


Mouse studies indicate successful pain relief, University of Pittsburgh researchers say



By "programming" a herpes simplex virus to deliver a gene-mediated pain-blocking protein at the cellular level, University of Pittsburgh researchers have been able to significantly reduce cancer-related pain in mice with tumors, the researchers report in the November issue of the journal Annals of Neurology. The paper, "Herpes vector-mediated expression of proenkephalin reduces bone cancer pain," is now available online at the journal’s Web site, http://www.interscience.wiley.com/jpages/0364-5134/.

"Chronic pain is notoriously difficult to treat effectively," said co-author Joseph Glorioso, Ph.D., chairman of the department of molecular genetics and biochemistry and director of the Molecular Medicine Institute at the University of Pittsburgh School of Medicine, and president of the American Society of Gene Therapy. "We’ve been able to show that using this virus can significantly reduce bone cancer pain – at least in mice."


The investigators are pursuing necessary approvals to begin a clinical trial in patients with severe pain resulting from metastatic cancer, and hope to start enrolling patients sometime next year.

"We are excited about the possibility that this approach may help to control pain in patients who can’t get complete relief from the maximum current treatment," said senior author David Fink, M.D., professor of neurology and molecular genetics and biochemistry at the University of Pittsburgh School of Medicine and chief of neurology and director of the Geriatric Research Education and Clinical Center at the Veterans Administration Pittsburgh Healthcare System.

Drs. Fink, Glorioso and their colleagues created an inactivated herpes simplex virus that carries the human gene for proenkaphalin, a naturally occurring painkilling peptide, a combination of amino acids.

Mice with tumors in a leg bone that received injections with the altered virus showed a substantial and significant reduction in pain-related behavior, the authors report.

"Although we have many powerful medications to treat pain, unwelcome side effects of these drugs limit our ability to relieve the most severe painful conditions," said Dr. Fink. "Using the virus to deliver the natural painkilling peptide may help in those cases."

These undesirable side effects can include excessive drowsiness, constipation and difficulty urinating.

"It remains to be seen how effective this may be in humans," said Dr. Glorioso. "But what we have seen so far is encouraging."


In addition to Drs. Fink and Glorioso, other authors include James Goss, Ph.D.; Marina Mata, M.D.; Cara Harley, B.S.; Xiaoping Hu and William Goins, Ph.D.

Additional Contact:
Michele D. Baum
Alan Aldinger
PHONE: (412) 647-3555
FAX: (412) 624-3184
E-MAIL:
BaumMD@upmc.edu
AldiAL@upmc.edu

Michele Baum | EurekAlert!
Further information:
http://www.interscience.wiley.com/jpages/0364-5134/
http://www.upmc.edu/

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>