Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer pain control possible with gene therapy

15.10.2002


Mouse studies indicate successful pain relief, University of Pittsburgh researchers say



By "programming" a herpes simplex virus to deliver a gene-mediated pain-blocking protein at the cellular level, University of Pittsburgh researchers have been able to significantly reduce cancer-related pain in mice with tumors, the researchers report in the November issue of the journal Annals of Neurology. The paper, "Herpes vector-mediated expression of proenkephalin reduces bone cancer pain," is now available online at the journal’s Web site, http://www.interscience.wiley.com/jpages/0364-5134/.

"Chronic pain is notoriously difficult to treat effectively," said co-author Joseph Glorioso, Ph.D., chairman of the department of molecular genetics and biochemistry and director of the Molecular Medicine Institute at the University of Pittsburgh School of Medicine, and president of the American Society of Gene Therapy. "We’ve been able to show that using this virus can significantly reduce bone cancer pain – at least in mice."


The investigators are pursuing necessary approvals to begin a clinical trial in patients with severe pain resulting from metastatic cancer, and hope to start enrolling patients sometime next year.

"We are excited about the possibility that this approach may help to control pain in patients who can’t get complete relief from the maximum current treatment," said senior author David Fink, M.D., professor of neurology and molecular genetics and biochemistry at the University of Pittsburgh School of Medicine and chief of neurology and director of the Geriatric Research Education and Clinical Center at the Veterans Administration Pittsburgh Healthcare System.

Drs. Fink, Glorioso and their colleagues created an inactivated herpes simplex virus that carries the human gene for proenkaphalin, a naturally occurring painkilling peptide, a combination of amino acids.

Mice with tumors in a leg bone that received injections with the altered virus showed a substantial and significant reduction in pain-related behavior, the authors report.

"Although we have many powerful medications to treat pain, unwelcome side effects of these drugs limit our ability to relieve the most severe painful conditions," said Dr. Fink. "Using the virus to deliver the natural painkilling peptide may help in those cases."

These undesirable side effects can include excessive drowsiness, constipation and difficulty urinating.

"It remains to be seen how effective this may be in humans," said Dr. Glorioso. "But what we have seen so far is encouraging."


In addition to Drs. Fink and Glorioso, other authors include James Goss, Ph.D.; Marina Mata, M.D.; Cara Harley, B.S.; Xiaoping Hu and William Goins, Ph.D.

Additional Contact:
Michele D. Baum
Alan Aldinger
PHONE: (412) 647-3555
FAX: (412) 624-3184
E-MAIL:
BaumMD@upmc.edu
AldiAL@upmc.edu

Michele Baum | EurekAlert!
Further information:
http://www.interscience.wiley.com/jpages/0364-5134/
http://www.upmc.edu/

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>