Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New data suggests chemotherapy patients benefit from heart failure treatment

25.09.2002


More than one-third of patients undergoing chemotherapy at risk for heart failure



Researchers at The University of Texas M. D. Anderson Cancer Center have found that cancer patients who develop heart failure as a result of chemotherapy treatment can be effectively treated, with the condition potentially reversed, when standard medicated therapy for heart failure is utilized.

The findings were presented today at the Sixth Annual Scientific Meeting of the Heart Failure Society of America in Boca Raton by Dr. Jean-Bernard Durand, assistant professor in the Department of Cardiology and director of Cardiomyopathy Service at M. D. Anderson.


The retrospective studies showed that patients treated with ACE-inhibitors and the beta-blocking agent, carvedilol, had significant improvements in two measures of heart failure: ejection fraction and New York Heart Association (NYHA) functional class . Previously, many cancer patients endured the invasive insertion of cardiac devices or full heart transplants in an effort to treat heart failure resulting from chemotherapy treatment.

The research has not been traditionally studied in cancer patients, and is believed to be the first to evaluate the treatment of heart failure using standard medication therapy in patients undergoing chemotherapy.

"Until now, heart failure was thought to be irreversible in chemotherapy patients with many cardiologists advising patients who develop the condition to reduce their chemotherapy regimens," say Dr. Durand, lead investigator for the study. "This data suggests that patients can continue their chemotherapy regimens, yet effectively reduce their risk of worsening heart failure and the eventual need for heart transplantation."

Heart failure develops when the heart is weakened and unable to pump blood efficiently through the body. It commonly results from damage to the heart after a heart attack, high blood pressure or diabetes. According to Dr. Durand, however, chemotherapeutic agents -- particularly at high doses -- may also cause direct injury to the heart, which can be potentially fatal or result in the need for heart transplantation and/or mechanical assistance heart devices. Dr. Durand says that 30 percent to 50 percent of chemotherapy patients will develop heart failure.

Dr. Durand presented today two retrospective studies evaluating the treatment of heart failure in chemotherapy patients. In one retrospective study, investigators reviewed the medical records of fifteen cancer inpatients with class IV heart failure evaluated in M. D. Anderson’s cardiomyopathy clinic. Cancer diagnosis, ejection fraction, recorded symptoms and hemodynamic data were examined before and after the use of intravenous inotropic agents, beta-blocking agents, ACE inhibitors and diuretics. Fourteen of the 15 patients achieved significant recovery of cardiac function and improvement in NYHA functional class following treatment and 13 patients were successfully discharged on a regimen of ACE inhibitors in combination with carvedilol.

In a second retrospective study, Dr. Durand and investigators reviewed the medical records from 16 cancer outpatients with mild to severe heart failure, diagnosed at initial evaluation in M. D. Anderson’s cardiomyopathy clinic. All 16 patients received standard combination therapy for heart failure, which included ACE inhibitors, diuretics and the beta-blocking agent carvedilol, unless unable to tolerate therapy. Ten patients had baseline left ventricular ejection fraction (LVEF) of less than 40 percent and six patients had LVEF of greater than 40 percent.

Results showed that carvedilol treatment alone yielded a mean increase in ejection fraction units in both groups of patients, 22 percent and 15 percent, respectively. Carvedilol in combination with an ACE inhibitor yielded a 25 percent increase in ejection fraction in patients with LVEF less than 40 percent and a 16 percent increase in patients with LVEF more than 40 percent.

"The data demonstrate that chemotherapy-induced heart failure may be reversible with standard medicated therapy for the condition," says Dr. Durand. "The implications of this research could lead to better chemotherapy regimens for patients without concern for developing a potentially fatal condition as a result of their cancer treatment."

M. D. Anderson researchers have proposed conducting a broader-scaled study in the near future to further analyze these observations.

Laura Sussman | EurekAlert!

More articles from Health and Medicine:

nachricht A better way to measure the stiffness of cancer cells
01.03.2017 | Duke University

nachricht Humans have three times more brown body fat
01.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

A better way to measure the stiffness of cancer cells

01.03.2017 | Health and Medicine

Exploring the mysteries of supercooled water

01.03.2017 | Physics and Astronomy

Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth

01.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>