Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Complex Changes in the Brain's Vascular System Occur after Menopause

19.06.2008
MU researchers advise extreme caution in prescribing estrogen-based hormone therapy

Many women experience menopausal changes in their body including hot flashes, moodiness and fatigue, but the changes they don’t notice can be more dangerous.

In a new study, researchers at the University of Missouri have discovered significant changes in the brain’s vascular system when the ovaries stop producing estrogen. MU scientists predict that currently used estrogen-based hormone therapies may complicate this process and may do more harm than good in postmenopausal women.

"Before menopause, women are much more protected from certain conditions such as heart disease and stroke, but these vascular changes might explain why women lose this protection after menopause," said Olga Glinskii, research assistant professor of medical pharmacology and physiology in MU’s School of Medicine and lead author of the study. “Because the body eventually will naturally adapt to the loss of estrogen, we advise extreme caution when using estrogen-based therapy in postmenopausal women.”

In their study, MU researchers removed the ovaries of pigs, which have a reproductive cycle similar to humans, to create postmenopausal conditions. Two months after the ovaries were removed, they observed dramatic differences in the brain’s vascular system. There was a huge loss of micro vessels, and blood vessels became “leaky.”

“Eventually, however, the body starts to recognize that it needs blood vessels and starts to adapt through natural responses,” said Vladislav Glinskii, assistant professor of pathology and anatomical sciences in MU’s School of Medicine, research health scientist at Harry S. Truman Memorial Veterans' Hospital and co-senior author of the study. “If we start adding estrogen to a system that is learning to adapt without it, we upset this transition process. What happens to the vascular system during menopause is complex on many different levels, and we do not know enough to determine the best way to use hormone therapy.

Before menopause, the vascular system depends on estrogen for maintenance. When the body decreases its estrogen production, the body is unable to regulate blood vessels like it did before. After a period of deterioration, the body learns to adapt to the estrogen loss and eventually maintains the system in a different way.

“The vascular system is like a roadmap that is always changing,” said Virginia Huxley, director of the National Center for Gender Physiology, professor of medical pharmacology and physiology in MU’s School of Medicine, and co-senior author of the study. “The blood vessels are the highways that transport oxygen and other nutrients in our body. After menopause, women are more likely to develop vascular diseases in the ‘side streets’ or the tiny vessels. In these vessels, the symptoms are more subtle and harder to identify.”

The study “PDGF/VEGF System Activation and Angiogenesis Following Initial Post Ovariectomy Meningeal Microvessel Loss,” was recently published in Cell Cycle.

Kelsey Jackson | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>