Many women experience menopausal changes in their body including hot flashes, moodiness and fatigue, but the changes they don’t notice can be more dangerous.
In a new study, researchers at the University of Missouri have discovered significant changes in the brain’s vascular system when the ovaries stop producing estrogen. MU scientists predict that currently used estrogen-based hormone therapies may complicate this process and may do more harm than good in postmenopausal women.
"Before menopause, women are much more protected from certain conditions such as heart disease and stroke, but these vascular changes might explain why women lose this protection after menopause," said Olga Glinskii, research assistant professor of medical pharmacology and physiology in MU’s School of Medicine and lead author of the study. “Because the body eventually will naturally adapt to the loss of estrogen, we advise extreme caution when using estrogen-based therapy in postmenopausal women.”
In their study, MU researchers removed the ovaries of pigs, which have a reproductive cycle similar to humans, to create postmenopausal conditions. Two months after the ovaries were removed, they observed dramatic differences in the brain’s vascular system. There was a huge loss of micro vessels, and blood vessels became “leaky.”
“Eventually, however, the body starts to recognize that it needs blood vessels and starts to adapt through natural responses,” said Vladislav Glinskii, assistant professor of pathology and anatomical sciences in MU’s School of Medicine, research health scientist at Harry S. Truman Memorial Veterans' Hospital and co-senior author of the study. “If we start adding estrogen to a system that is learning to adapt without it, we upset this transition process. What happens to the vascular system during menopause is complex on many different levels, and we do not know enough to determine the best way to use hormone therapy.
Before menopause, the vascular system depends on estrogen for maintenance. When the body decreases its estrogen production, the body is unable to regulate blood vessels like it did before. After a period of deterioration, the body learns to adapt to the estrogen loss and eventually maintains the system in a different way.
“The vascular system is like a roadmap that is always changing,” said Virginia Huxley, director of the National Center for Gender Physiology, professor of medical pharmacology and physiology in MU’s School of Medicine, and co-senior author of the study. “The blood vessels are the highways that transport oxygen and other nutrients in our body. After menopause, women are more likely to develop vascular diseases in the ‘side streets’ or the tiny vessels. In these vessels, the symptoms are more subtle and harder to identify.”
The study “PDGF/VEGF System Activation and Angiogenesis Following Initial Post Ovariectomy Meningeal Microvessel Loss,” was recently published in Cell Cycle.
Kelsey Jackson | EurekAlert!
On track to heal leukaemia
18.01.2017 | Universitätsspital Bern
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences