For the study, researchers identified 49,349 US veterans age 55 and older who developed Alzheimer’s disease and 196,850 veterans without dementia. The study examined over five years of data and looked at the use of several non-steroidal anti-inflammatory drugs (NSAIDs). The veterans received medical care and prescriptions through the VA Health Care system.
The study found people who specifically used ibuprofen for more than five years were more than 40 percent less likely to develop Alzheimer’s disease. Results also showed that the longer ibuprofen was used, the lower the risk for dementia. In addition, people who used certain types of NSAIDs for more than five years were 25 percent less likely to develop Alzheimer’s disease than non-users.
While other NSAIDs such as indomethacin may also have been associated with lower risks, others such as celecoxib did not show any impact on dementia risk. “These results suggest that the effect may be due to specific NSAIDs rather than all NSAIDs as a class,” said study author Steven Vlad, MD, with Boston University School of Medicine.
“Some of these medications taken long term decrease the risk of Alzheimer’s disease, but it’s very dependent on the exact drugs used. It doesn’t appear that all NSAIDs decrease the risk at the same rate,” said Vlad. “One reason ibuprofen may have come out so far ahead is that it is by far the most commonly used.”
Observational studies such as this one must be interpreted with the understanding that they do not prove that an NSAID has a therapeutic effect. The study is subject to what is called “indication bias.” That means that it might not be the NSAID use that drove the lower risk of dementia, but rather something about the people who chose to use the NSAIDs that was responsible. These findings should not be taken to mean that NSAIDs should be administered to prevent dementia.
The most common side effects of NSAIDs are nausea, vomiting, diarrhea, dizziness, constipation and headache.
The study was supported by grants from the National Institutes of Health.
The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and multiple sclerosis.
Angela Babb | American Academy of Neurology
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
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19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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