Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Quick blood test for malaria

01.08.2014

Siemens is working on a procedure that would allow blood to be routinely tested for malaria.

Physicians normally diagnose the tropical disease by using a microscope to search for parasites in blood samples. The problem is that practically every instance of fever in countries where the disease is common is treated with antimalarial drugs, despite the fact that doctors don't even know if the patient is afflicted with malaria.


Conversely, doctors in countries where malaria is rare often don't associate their patients' symptoms with the tropical fever and therefore don't make the correct diagnosis. As reported in the Siemens research ma­gazine Pictures of the Future, scientists from Siemens' research department Corporate Technology (CT) have now developed a method that can detect malaria using information from a standard blood test. The scientists' goal is to implement the new procedure in Siemens' ADVIA 2010 hematology system, which is now being used in many hospitals around the world.

Malaria is one of the world's most devastating tropical diseases. According to the World Health Organization, some 200 million people became afflicted in 2012, and more than 600,000 people died. It's difficult to make a proper diagnosis because the symptoms can have many different causes. Medical lab technicians also need to have a lot of experience to identify malaria parasites under a microscope.

Experts say that only around ten percent of actual cases worldwide are diagnosed as such. Being able to detect the disease through a blood test would improve the situation. The problem up until now was that although malaria does change certain blood attributes, such as the number of platelets, the same is also true of other illnesses.

The idea was to identify a malaria affliction on the basis of a distinct combination of several different blood attributes. Together with colleagues from Siemens Healthcare, CT researchers analyzed anonymous blood data from samples taken from both healthy individuals and malaria patients.

They initially selected parameters that might potentially be related to malaria from the hundreds of measurement values produced by the ADVIA system. They then used statistical methods to search for distinct blood value patterns in the samples taken from malaria patients. In this manner, they developed a formula for searching for these "malaria patterns" in blood sample data.

Their technique can also be adapted to different situations. For example, sometimes it's important to be able to detect malaria even if the number of parasites present in blood is very low - i.e. the triggers must be very sensitive. In other situations, doctors want to be very certain they're making the right diagnosis in order to avoid false alarms. The new formula for malaria diagnosis performs very well with respect to both sensitivity and specificity.

The formula is based on the blood values associated with the most common form of malaria. The researchers are further developing their method in order to be able to distinguish between the seven different types of malaria and to test how well their method diagnoses each of them. They are also analyzing additional blood data sets from different regions around the world with the goal of making their procedure even more robust. 

Weitere Informationen:

http://www.siemens.com/innovationnews

Dr. Norbert Aschenbrenner | Siemens InnovationNews

Further reports about: ADVIA CT Technology blood common diagnosis fever identify malaria parasites symptoms tropical

More articles from Health and Medicine:

nachricht Using DNA origami to build nanodevices of the future
31.08.2015 | Institute for Integrated Cell-Material Sciences at Kyoto University

nachricht An ounce of prevention: Research advances on 'scourge' of transplant wards
28.08.2015 | University of Wisconsin-Madison

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Increasingly severe disturbances weaken world's temperate forests

Longer, more severe, and hotter droughts and a myriad of other threats, including diseases and more extensive and severe wildfires, are threatening to transform some of the world's temperate forests, a new study published in Science has found. Without informed management, some forests could convert to shrublands or grasslands within the coming decades.

"While we have been trying to manage for resilience of 20th century conditions, we realize now that we must prepare for transformations and attempt to ease...

Im Focus: OU astrophysicist and collaborators find supermassive black holes in quasar nearest Earth

A University of Oklahoma astrophysicist and his Chinese collaborator have found two supermassive black holes in Markarian 231, the nearest quasar to Earth, using observations from NASA's Hubble Space Telescope.

The discovery of two supermassive black holes--one larger one and a second, smaller one--are evidence of a binary black hole and suggests that supermassive...

Im Focus: What would a tsunami in the Mediterranean look like?

A team of European researchers have developed a model to simulate the impact of tsunamis generated by earthquakes and applied it to the Eastern Mediterranean. The results show how tsunami waves could hit and inundate coastal areas in southern Italy and Greece. The study is published today (27 August) in Ocean Science, an open access journal of the European Geosciences Union (EGU).

Though not as frequent as in the Pacific and Indian oceans, tsunamis also occur in the Mediterranean, mainly due to earthquakes generated when the African...

Im Focus: Self-healing landscape: landslides after earthquake

In mountainous regions earthquakes often cause strong landslides, which can be exacerbated by heavy rain. However, after an initial increase, the frequency of these mass wasting events, often enormous and dangerous, declines, in fact independently of meteorological events and aftershocks.

These new findings are presented by a German-Franco-Japanese team of geoscientists in the current issue of the journal Geology, under the lead of the GFZ...

Im Focus: FIC Proteins Send Bacteria Into Hibernation

Bacteria do not cease to amaze us with their survival strategies. A research team from the University of Basel's Biozentrum has now discovered how bacteria enter a sleep mode using a so-called FIC toxin. In the current issue of “Cell Reports”, the scientists describe the mechanism of action and also explain why their discovery provides new insights into the evolution of pathogens.

For many poisons there are antidotes which neutralize their toxic effect. Toxin-antitoxin systems in bacteria work in a similar manner: As long as a cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Networking conference in Heidelberg for outstanding mathematicians and computer scientists

20.08.2015 | Event News

Scientists meet in Münster for the world’s largest Chitin und Chitosan Conference

20.08.2015 | Event News

Large agribusiness management strategies

19.08.2015 | Event News

 
Latest News

Time travel into the past of marginal seas: IOW expedition explores Canadian coastal waters

31.08.2015 | Earth Sciences

Using DNA origami to build nanodevices of the future

31.08.2015 | Health and Medicine

10. Workshop Magnetlagertechnik Zittau-Chemnitz

31.08.2015 | Seminars Workshops

VideoLinks
B2B-VideoLinks
More VideoLinks >>>