Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

PolyU study sheds new light on anti-inflammatory mechanism of unique marine oil

26.01.2009
A pioneering research by The Hong Kong Polytechnic University (PolyU) has uncovered the previously unknown anti-inflammatory mechanism for soothing the pain arising from arthritis, and thus unlocked the key to conducting further researches on the relationship between functional foods and this common crippling disease.

This research was undertaken by a team led by Professor Samuel Lo Chun-lap of the Department of Applied Biology and Chemical Technology in the University’s Proteomics Laboratory. The team was intrigued by whether consumption of a food supplement would alleviate the symptom of arthritis, and they started with testing the oil of Perna canaliculus, the green-lipped mussel of New Zealand, on rats with adjuvant-induced arthritis.

In a series of studies conducted by Professor Lo and his team, the oil extract was shown to be able to relieve pain in the animals; modulate cytokines with a decrease in cytokines associated with inflammation, and lead to an increase in IL-10 (a cytokine that controls inflammation).

More importantly, the oil extract decreased the synthesis of some proteins associated with inflammation, while increasing the synthesis of the anti-inflammatory enzyme MDH. Decreased expression of proteins related to inflammation was uncovered by proteomic technologies. This discovery has therefore cast new light on the anti-inflammatory function of this oil and the underlying mechanism of soothing arthritis.

The result of this ground-breaking study was published under the title of “Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis” in the Inflammopharmacology journal in 2008.

Encouraged by the findings, PolyU researchers are planning to test the anti-inflammatory functions of other common foods as well as Chinese herbs. They will also involve athletes and sportsmen besieged by arthritis in the next stage of research. Prof. Lo will be working alongside with Associate Professor Dr Mason Leung of the University’s Department of Rehabilitation Sciences in the next stage.

The oil of Perna canaliculus, the green-lipped mussel of New Zealand, when extracted by super-critical extraction is free of protein and carbohydrate. A large number of studies have been published on its composition, complex mode of action, activity in animal models, and efficacy in controlling osteoarthritis and moderate asthma in patients.

These studies were supported in part by an unrestricted grant for education and research from Pharmalink International Ltd.

Press Contact: Professor Samuel Lo
Department of Applied Biology and Chemical Technology
Telephone: (852) 3400 8669
E-mail: bcsamlo@polyu.edu.hk

Yu Kit Sun Regina | ResearchSEA
Further information:
http://www.polyu.edu.hk
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>