This research was undertaken by a team led by Professor Samuel Lo Chun-lap of the Department of Applied Biology and Chemical Technology in the University’s Proteomics Laboratory. The team was intrigued by whether consumption of a food supplement would alleviate the symptom of arthritis, and they started with testing the oil of Perna canaliculus, the green-lipped mussel of New Zealand, on rats with adjuvant-induced arthritis.
In a series of studies conducted by Professor Lo and his team, the oil extract was shown to be able to relieve pain in the animals; modulate cytokines with a decrease in cytokines associated with inflammation, and lead to an increase in IL-10 (a cytokine that controls inflammation).
More importantly, the oil extract decreased the synthesis of some proteins associated with inflammation, while increasing the synthesis of the anti-inflammatory enzyme MDH. Decreased expression of proteins related to inflammation was uncovered by proteomic technologies. This discovery has therefore cast new light on the anti-inflammatory function of this oil and the underlying mechanism of soothing arthritis.
The result of this ground-breaking study was published under the title of “Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis” in the Inflammopharmacology journal in 2008.
Encouraged by the findings, PolyU researchers are planning to test the anti-inflammatory functions of other common foods as well as Chinese herbs. They will also involve athletes and sportsmen besieged by arthritis in the next stage of research. Prof. Lo will be working alongside with Associate Professor Dr Mason Leung of the University’s Department of Rehabilitation Sciences in the next stage.
The oil of Perna canaliculus, the green-lipped mussel of New Zealand, when extracted by super-critical extraction is free of protein and carbohydrate. A large number of studies have been published on its composition, complex mode of action, activity in animal models, and efficacy in controlling osteoarthritis and moderate asthma in patients.
These studies were supported in part by an unrestricted grant for education and research from Pharmalink International Ltd.Press Contact: Professor Samuel Lo
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology