Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Step Towards Eradication of H5N1 Bird Flu

03.11.2014

A University of Adelaide-led project has developed a new test that can distinguish between birds that have been vaccinated against the H5N1 strain of avian influenza virus or “bird flu” with those that have been naturally infected.

This is a significant step in the fight against this often fatal strain of avian influenza which is widespread in the poultry populations of South East Asia, particularly Indonesia and Vietnam.

It causes global concern because of its possible transmission to humans and the threat of a pandemic if it mutates to a form that can be easily passed from bird to human then human to human. The research has been published in PLOS ONE.

“Avian flu is on the top list of notifiable diseases of the World Organization for Animal Health (OIE) because of its high economic cost and risk to human health,” says project leader Dr Farhid Hemmatzadeh, Senior Lecturer in Virology in the School of Animal and Veterinary Sciences at the Roseworthy campus.

“Outbreaks in birds are largely being controlled by vaccination and this is limiting human exposure to this virus.

“But the inability of distinguishing between vaccinated and naturally infected birds has been a major challenge. It has prevented tracking the virus which can still circulate in vaccinated birds and may mutate to new strains under what’s called vaccination pressure.

“These birds that have been vaccinated but still have live naturally infected H5N1 virus in their systems are the main source of emerging strains of the virus - and these new strains may be even more dangerous to birds or humans.

“With this new, more sensitive, test we can identify these vaccinated birds with live virus and prevent the escape of any mutant strains. This is essential if we want to prevent pandemics developing from this virus and eventually eradicate this disease.”

The researchers, including the University of Melbourne, CSIRO and Indonesian organisations, are carrying out large surveillance programs in poultry farms across Indonesia. The research is funded by the Australian Centre for International Agricultural Research (ACIAR).

The bird vaccine is made from avian influenza virus which has been killed but still promotes the production of antibodies in the bird protecting it against the live virus. The antibodies prevent the replication of the virus in the bird, but in some cases the virus mutates in a vaccinated bird and can still replicate even with the existing high level of antibodies to the vaccines.

The new DIVA test (differentiation of infected from vaccinated animals) uses a particular viral protein called Matrix protein 2 that reacts differently with blood serum from vaccinated or infected animals. Since the first outbreak of H5N1 avian influenza virus in 2004, the development of a reliable DIVA test has been global priority.

Media Contact:

Dr Farhid Hemmatzadeh
Senior Lecturer, School of Animal and Veterinary Sciences
The University of Adelaide
Phone: +61 8 8313 7723
Mobile: +61 (0)410 749 766
farhid.hemmatzadeh@adelaide.edu.au

Robyn Mills
Media and Communications Officer
The University of Adelaide
Phone: +61 8 8313 6341
Mobile: +61 410 689 084
robyn.mills@adelaide.edu.au

Robyn Mills | newswise
Further information:
http://www.adelaide.edu.au

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>