Breathing oxygen helps the body create energy for its cells. As a result of the breathing process, reactive molecules called “free radicals” are produced that often cause damage to proteins and genes found in cells. This damage is known as oxidative stress. Free radicals also have been linked to cancer, Alzheimer’s and Parkinson’s disease. Now, investigators at the University of Missouri have discovered a molecule that treats oxidative stress.
“Oxidative stress can cause damage to the building blocks of a cell, resulting in excessive cell proliferation, in the case of cancer or cell death, in the case of neurodegenerative diseases like Parkinson’s,” said Mark Hannink, a professor in the Department of Biochemistry and an investigator at the Bond Life Sciences Center at MU. “Finding the right balance is like walking a tightrope; our work has focused on finding ways to keep oxidative stress at bay.”
Hannink and his team discovered a molecule that treats oxidative stress.
Hannink partnered with High Point Pharmaceuticals LLC, a North Carolina-based firm, to find the right combinations of molecules to create an effective drug that fights free radicals. Using tools developed in his lab, Hannink and Kim Jasmer, a graduate student in Hannink’s lab, analyzed a group of molecules developed by the pharmaceutical company that could be good candidates for treating oxidative stress. They identified a particular compound, known as HPP-4382 that has been proven effective in fighting oxidative stress and could eventually be developed into a drug. The molecule has been patented by High Point.
“Kim developed the research tools needed to identify the right molecular candidates making the research more effective and efficient,” Hannink said. “We found the right molecule that corrects the imbalance of oxidative stress and could one day have wide applicability. Because of this study, we have a better understanding of what these compounds are doing to counteract oxidative stress.
The work adds to a pipeline of molecular clinical and pre-clinical drug candidates for the treatment of oxidative stress and serves as a good starting point for researchers to find similar compounds, Hannink said.
The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, these compounds may be tested in human clinical trials with the hope of developing new treatments for diseases that are characterized by the over-production of free radicals and oxidative stress.
The research, “Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity” was published in PLOS One with funding from High Point Pharmaceuticals.
Editor’s Note: For a longer version of this story, please visit: “The search for oxidative stress treatment continues.”
Jeff Sossamon | Eurek Alert!
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
On track to heal leukaemia
18.01.2017 | Universitätsspital Bern
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy