It is difficult to determine potential health effects from this condition because of humans’ relatively long life-spans. Now, researchers at the University of Missouri have found that microchimerism can be found in dogs as well.
Jeffrey Bryan, an associate professor of oncology at the MU College of Veterinary Medicine and director of Comparative Oncology and Epigenetics Laboratory, says this discovery will help doctors determine what diseases humans with microchimerism may be more likely to develop during their lifetimes.
“Dogs have a much shorter lifespan than humans, which allows us, as researchers, to better monitor what diseases they may develop throughout their entire lives,” Bryan said. “We already have some evidence that microchimerism may increase risk of thyroid disease while lowering the risk of breast cancer in women. Finding microchimerism in dogs allows us to track this condition over a lifespan of about 10 years, as opposed to the 70 or 80 years of a human life. This will make it much easier to determine any increased risk of or protection from other diseases brought on by microchimerism.”
“Our study demonstrates that male microchimerism of probable fetal origin occurs in the pet dog population,” said Sandra Axiak-Bechtel, an assistant professor of oncology at the MU College of Veterinary Medicine. “Evidence exists in women that fetal microchimerism may have conflicting roles in disease formation. The pet dog represents an excellent model of many ailments in people, and the presence of fetal microchimerism in dogs will allow studies which further clarify its role in health and disease.”
Microchimerism most often occurs when a mother gives birth to a child. Sometimes, cells from that child are left in the mothers’ body and continue to live, despite being of a different genetic makeup than surrounding cells. Those cells can then be passed on to other children the mother may have later. Cells also can be passed on through blood transfusions as well as bone marrow and organ transplants.
In their study published in PLOS ONE, Bryan and Axiak-Bechtel, along with MU researchers Senthil Kumar, a co-investigator in this study and assistant research professor and assistant director of the Comparative Oncology and Epigenetics Laboratory, and Sara Hansen, a comparative medicine resident at MU, studied 90 golden retrievers and found that 36 percent of the dogs had microchimerism. Closer to 40 percent of female dogs that were at least eight years post-pregnancy had the condition.
Axiak-Bechtel, Bryan, and Kumar plan on continuing their research to follow the lifespans of dogs with microchimerism to determine to what diseases those dogs may be susceptible. Bryan and Kumar also received a new grant for more than $400,000 to study epigenetic biomarkers in dogs, which will ultimately enhance diagnosis and treatment of dogs with cancer.
Nathan Hurst | EurekAlert!
Got good fat?
27.04.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn
Successful laboratory test of photoswitchable anti-tumor agent
25.04.2016 | Karlsruher Institut für Technologie (KIT)
Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.
Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.
In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...
Honeycomb structures as the basic building block for industrial applications presented using holo pyramid
Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...
Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.
Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...
As one of the leading R&D partners in the development of surface technologies and organic electronics, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP will be exhibiting its recent achievements in vacuum coating of ultra-thin glass at SVC TechCon 2016 (Booth 846), taking place in Indianapolis / USA from May 9 – 13.
Fraunhofer FEP is an experienced partner for technological developments, known for testing the limits of new materials and for optimization of those materials...
27.04.2016 | Event News
15.04.2016 | Event News
12.04.2016 | Event News
29.04.2016 | Life Sciences
28.04.2016 | Physics and Astronomy
28.04.2016 | Materials Sciences