Patients in intensive care units (ICU) are often administered antibiotics against ventilator-associated pneumonia, ‘to be on the safe side’. Dutch researcher Stefan Visscher has developed a model that can quickly establish whether or not a patient has pneumonia. This can prevent unnecessary treatment with antibiotics.
In his thesis Stefan Visscher studied 238 cases of antibiotic treatment of which – with hindsight – only 157 patients were actually suffering from pneumonia. An absence of suitable patient-friendly tests makes it difficult to determine with certainty whether or not a patient has developed pneumonia.
Visscher developed and tested a Bayesian network model, a probabilistic model, that can distinguish between patients that do and do not have ventilator-associated pneumonia (VAP). His model calculates the probability that an individual patient is suffering from pneumonia, predicts which bacteria has caused it and indicates which antibiotic can best be prescribed. This method is more reliable than the cultures on which physicians currently base their decisions. The data needed to make the probability calculations are automatically retrieved from the electronic patient file.
In his model Visscher processed the clinical data and other details of all ventilated ICU patients over a period of three years. The computer models were initially based on expert knowledge. At a later stage this was enhanced with ‘machine-learning’ techniques in order to optimise the reliability of the predictions where needed.Electronic patient file
The research was carried out within the ToKeN programme of NWO Division for Physical Sciences, www.nwo.nl/token.
Kim van den Wijngaard | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy