Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MicroRNAs: A potential new frontier for medicine

24.03.2011
Noted experts explore this topic in the April issue of Translational Research

Since their discovery in the 1990s, microRNAs have proven to play a complex role in normal and abnormal functioning of many organ systems. In the April issue of Translational Research, entitled "MicroRNAs: A Potential New Frontier for Medicine," an international group of medical experts explores several themes related to our current understanding of microRNAs and the role they may play in the future of medicine.

A commentary by Monty Montano, Department of Medicine, Boston University, provides a general introduction to this single-topic issue. He states, "In the coming years, there is much to be learned about adaptive (and maladaptive) states by examining how the expression of miRNAs is influenced by the genetic architecture of miR genes, clusters, and mirtrons, as well as miRNA polymorphism and polymorphism in their mRNA targets…Current efforts to leverage knowledge of this regulatory system to diagnose, track, and attenuate disease progression represent a major new research opportunity and challenge in this rapidly growing area of translational medicine."

KEY POINTS:

microRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
Rujuan Dai, and S. Ansar Ahmed
The authors review in great detail the functions of microRNAs in autoimmune diseases, inflammation processes, and immune system regulation.
Integrating microRNAs into a system biology approach to acute lung injury
Tong Zhou, Joe G.N. Garcia and Wei Zhang
The authors explore the possible role of microRNAs in inflammatory lung diseases and integration into a comprehensive disease model for acute lung injury.
MicroRNAs in idiopathic pulmonary fibrosis
Kusum V. Pandit, Jadranka Milosevic and Naftali Kaminski
The authors summarize current knowledge on the role of microRNAs in idiopathic lung fibrosis (IPF), highlighting how differentially expressed microRNAs in IPF will have a significant impact on our understanding of the disease.
Involvement of microRNAs in lung cancer biology and therapy
Xi Liu, Lorenzo F. Sempere, Yongli Guo, Murray Korc, Sakari Kauppinen, Sarah J. Freemantle and Ethan Dmitrovsky

The authors review how microRNAs can accelerate or suppress lung cancers and how this knowledge might serve as a basis for developing diagnostic markers or anti-cancer therapeutic agents.

MicroRNA biomarkers in lung cancer: MiRacle or quagMiRe?
Sai Yendamuri and Robert Kratzke
The authors explore some of the difficulties facing the development of microRNAs as biomarkers for lung disease, as well as some promising areas of research.
MicroRNAs as therapeutic targets in cancer
S. Patrick Nana-Sinkam and Carlo M. Croce
The authors review the challenges of translating current knowledge on microRNAs into effective clinical therapies for many cancers or as adjuvants for enhancing chemosensitivity to traditional therapies.
MicroRNAs in cardiac disease
Gerald W. Dorn II
The author examines the use of microRNAs as both biomarkers of cardiac diseases and as potential targets for therapies.
MicroRNAs in kidney function and disease
Sanjeev Akkina and Bryan N. Becker
The authors review the role of microRNAs in understanding the pathophysiology of kidney disease and potential therapeutic uses.
microRNAs and liver disease
Thomas A. Kerr, Kevin M. Korenblat and Nicholas O. Davidson
The authors review developments in microRNA research in the areas of pathogenesis of nonalcoholic fatty liver disease (NAFLD), viral hepatitis (C and B), and hepatocellular carcinoma (HCC), as well as the role of miRNAs as biomarkers of liver injury and HCC.
Diabetes mellitus, a microRNA-related disease?
Claudiane Guay, Elodie Roggli, Valeria Nesca, Cécile Jacovetti and Romano Regazzi

The authors review recent studies on the role of microRNAs in the pathogenesis of diabetes, including the role of several microRNAs in pancreatic beta cells and insulin-target tissues.

These articles appear in Translational Research, The Journal of Laboratory and Clinical Medicine, Volume 157, Issue 4 (April 2011) entitled "MicroRNAs: A Potential New Frontier for Medicine," published by Elsevier.

Pat Hogan | EurekAlert!
Further information:
http://www.elsevier.com

More articles from Health and Medicine:

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>