Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The Mental Health Dangers of Birth Hypoxia

28.10.2008
Lower Levels of a Protein Measured at Birth is Associated with an Increased Risk of Developing Schizophrenia as an Adult

Complications during pregnancy and birth, such as birth hypoxia - the shortage of oxygen in the body - are associated with an increased risk for schizophrenia.

However, it is not clear why hypoxia increases the risk for schizophrenia. The November 1st issue of Biological Psychiatry includes an article by researchers who show that the presence of a specific indicator of fetal distress following hypoxia was more likely to be present among people who later develop schizophrenia. Their findings suggest that the inability of a high-risk fetus to respond adequately to metabolic stresses that it faces in the womb may contribute to its later risk for developing schizophrenia.

Specifically, the authors analyzed levels of an important neuroprotective protein – brain-derived neurotrophic factor (BDNF) - in umbilical cord and maternal blood serum samples obtained at the time of birth and stored in a repository for 45-50 years. They then compared the levels of BDNF found among those individuals who had developed schizophrenia during their lifetime to control subjects, i.e., those individuals who did not develop the disorder. Dr. Tyrone Cannon, the corresponding author, explains the findings: “We found that while BDNF was increased (by 10%) among controls exposed to birth hypoxia, it was significantly decreased (by 20%) among [people later diagnosed with schizophrenia who were] exposed to birth hypoxia.” John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments that this data “suggests that schizophrenia is not simply associated with deficits in BDNF, but rather it is associated with BDNF reductions at a critical moment in the development of the brain when it needs BDNF to cope with a serious metabolic challenge.”

Although this is a preliminary study, and the results need replication, the authors note that this may lead to the study of “novel molecular targets for preventive intervention.” The idea of prevention is an important target, as these findings promote “the public health message that maintaining maternal health during pregnancy and reducing the factors that might contribute to the metabolic compromise of the fetus might have real payoff in reducing the later risk for schizophrenia of that fetus,” posits Dr. Krystal. That science may one day have the ability to identify these high-risk individuals from birth would be a tremendous advantage in the struggle against this disabling condition.

Jayne Dawkins | alfa
Further information:
http://www.elsevier.com/

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>