Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gut microbes could determine the severity of melamine-induced kidney disease

14.02.2013
Microbes present in the gut can affect the severity of kidney disease brought on by melamine poisoning, according to an international study led by Professor Wei Jia at the University of North Carolina in collaboration with the research group of Professor Jeremy Nicholson at Imperial College London.

In 2008, nearly 300,000 Chinese children were hospitalised with kidney disease brought on by supplies of powdered milk deliberately contaminated with melamine to boost the apparent protein content. Although melamine was known to combine with uric acid in the children's bodies to produce harmful kidney stones, the details of the reaction and the role of specific gut microbes were not well understood.

By studying how melamine contributes to the development of kidney stones in rats, the research groups have shown experimentally that gut microbes may be central to understanding melamine-induced kidney failure in humans.

The formation of kidney stones occurs when melamine reacts with cyanuric acid in the kidney to form crystals which cannot be dissolved in the bloodstream. According to the paper, published today in Science Translational Medicine, certain species of gut microbes are responsible for converting melamine into the toxic cyanuric acid, thereby accelerating the rate at which kidney stones are formed.

Tests on rats showed that the presence of microbes of the Klebsiella family tended to facilitate the process of melamine conversion, potentially making them key players in the formation of kidney stones. This study suggests that toxicity in this case is linked to the make-up of gut microbes in the poisoned organism.

"The metabolic activities of gut microbes strongly influence human health in profound ways and have been linked to the development of multiple medical problems ranging from autoimmune diseases, obesity, diabetes, and cardiovascular disease," said Professor Nicholson, head of the Department of Surgery and Cancer at Imperial. "The specific implication of this research is that the expression of the kidney disease in the Chinese contaminated milk scandal is likely to have been mediated by gut bacteria in affected children. The more general implication is that gut microbial status affects the outcome to exposures to environmental and food contaminants."

For further information please contact:

Gilead Amit
Covering Research Media Officer
Imperial College London
Out of hours duty press officer: 44-0-7803-886-248
Notes to editors:
1. "Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota" Science Translational Medicine journal, published in print Wednesday 13 February 2013

Xiaojiao Zheng, Aihua Zhao, Guoxiang Xie, Yi Chi, Linjing Zhao, Houkai Li, Congrong Wang, Yuqian Bao, Weiping Jia, Mike Luther, Mingming Su, Jeremy K. Nicholson* and Wei Jia *Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, UK.

A copy of the published paper: http://stm.sciencemag.org/content/5/172/172ra22.full.

2. About Imperial College London

Consistently rated amongst the world's best universities, Imperial College London is a science-based institution with a reputation for excellence in teaching and research that attracts 14,000 students and 6,000 staff of the highest international quality. Innovative research at the College explores the interface between science, medicine, engineering and business, delivering practical solutions that improve quality of life and the environment - underpinned by a dynamic enterprise culture.

Since its foundation in 1907, Imperial's contributions to society have included the discovery of penicillin, the development of holography and the foundations of fibre optics. This commitment to the application of research for the benefit of all continues today, with current focuses including interdisciplinary collaborations to improve global health, tackle climate change, develop sustainable sources of energy and address security challenges. In 2007, Imperial College London and Imperial College Healthcare NHS Trust formed the UK's first Academic Health Science Centre. This unique partnership aims to improve the quality of life of patients and populations by taking new discoveries and translating them into new therapies as quickly as possible.

Gilead Amit | EurekAlert!
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>