Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug inhibits infection with cause of watery diarrhea

08.07.2015

Understanding mechanism of Cryptosporidium infection will support drug development

Researchers at the University of Tokyo and Obihiro University of Agriculture and Veterinary Medicine have demonstrated that heparin, a type of sulfated polysaccharide, inhibits infection with Cryptosporidium parvum, a protozoan that causes diarrhea in humans and other mammals. This will facilitate the development of anti-cryptosporidial agents.


Life cycle of Cryptosporidium and inhibitory efficacy of heparin. (Upper) Life cycle of Cryptosporidium. (Bottom) Inhibitory efficacy of heparin on Cryptosporidium infection is concentration dependent (increases with concentration). © 2015 Kentaro Kato.

Cryptosporidium is zoonotic pathogen (a pathogen that causes disease in animals and which can also infect humans), which infects a wide range of mammals including humans and cattle causing severe diarrhea.

The pathogen can cause outbreaks in humans through tap water because of its resistance to chlorination, and economic loss for farmers by infecting and causing severe diarrhea in young calves.

Therefore, the livestock sector requires effective measures against the pathogen and investigation of the mechanism of infection and development of new medicines are urgently needed.

In this study, Associate Professor Kentaro Kato and his group at the University of Tokyo Graduate School of Agricultural and Life Sciences and Obihiro University of Agriculture and Veterinary Medicine investigated whether sulfated polysaccharides inhibit infection by the Cryptosporidium parasite using cells derived from human colon tissue.

The group showed for the first time that heparin inhibits the infection of Cryptosporidium, and that the greater the concentration of heparin the greater the inhibitory effect.

In addition, the group investigated the mechanism of infection by the Cryptosporidium parasite, and elucidated that heparan sulfate, a sulfated polysaccharide found on the surface of mammalian cells, is involved in Cryptosporidium infection.

“This study will further promote our understanding of the interaction of heparin sulfate with Cryptosporidium and the mechanism of Cryptosporidium infection, and will facilitate the development of anti-cryptosporidial agents,” says Associate Professor Kato.

Paper

Atsuko Inomata, Fumi Murakoshi, Akiko Ishiwa, Ryo Takano, Hitoshi Takemae, Tatsuki Sugi, Frances Cagayat Recuenco, Taisuke Horimoto, and Kentaro Kato, "Heparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion", Scientific Reports Online Edition: 2015/7/1 (Japan time), doi: 10.1038/srep11599.


Associated links
U Tokyo Research article

Euan McKay | ResearchSEA
Further information:
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>