Not only does it affect a person's ability to concentrate and make decisions, it also alters their ability to experience pleasurable emotion, and instead prolongs negative thoughts and feelings. New research published in BioMed Central's open access journal Biology of Mood & Anxiety Disorders used functional magnetic resonance imaging (fMRI) to show aberrant connectivity in depressed brains.
Researchers from Stanford University compared the fMRI scans of women who were resting (but still awake). Half of the women were diagnosed with depression at the time of the scan and the other group consisted of women who did not currently have, nor had ever had, severe depression.
fMRI measures changes in blood flow and by overlaying images of depressed and unaffected brains, a number of differences came to light. The images showed that the depressed had decreased connectivity between several key regions of the brain responsible for emotional behaviour, learning, memory and decision making.
Daniella Furman explained, "In addition to decreased connectivity between emotion processing regions of the brain, we found that depression was linked to an increase in connectivity between the dorsal caudate and an area of the prefrontal cortex. Deep within the brain, the caudate is thought to be involved in learning, motivation, and emotion while the prefrontal cortex at the front of the head is involved in maintaining goals and likely regulating emotional behaviour. Together, these regions may act to filter out irrelevant thoughts or actions."
She continued, "Greater connectivity between the dorsal caudate and prefrontal cortex might reflect the inability of the depressed to update their working memory and, as a result, sustains negative thoughts. In fact we found evidence for a parallel increase in tendency to ruminate on bad thoughts."Media Contact
Guy Melzack | EurekAlert!
Spanish scientists create a 3-D bioprinter to print human skin
24.01.2017 | Carlos III University of Madrid
Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital
A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
24.01.2017 | Physics and Astronomy
24.01.2017 | Life Sciences
24.01.2017 | Health and Medicine