Women who receive radiation therapy as children and young adults for diseases like Hodgkin's lymphoma face a significantly greater risk of breast cancer later in life.
The incidence of breast cancer increases approximately eight years after chest irradiation, and 13 percent to 20 percent of women treated with moderate- to high-dose chest irradiation for a pediatric cancer will be diagnosed with breast cancer by age 40 to 45. In comparison, the cumulative incidence of invasive breast cancer by age 45 among women in the general population is only 1 percent.
"MRI's efficacy as an adjunct to mammography in screening women at high risk because of genetic mutation or family history has been established," said the study's lead author Janice S. Sung, M.D., radiologist at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City. "However, there were no reports in the literature about utility of MRI screening in women who are at high risk specifically due to prior chest irradiation."
In the study, Dr. Sung and colleagues reviewed screening breast MRIs performed at MSKCC between January 1999 and December 2008 on women with a history of chest irradiation. They looked at data from 247 screening breast MRIs in 91 women, with a focus on the number of cancers diagnosed, the method of detection and the tumor characteristics.
Of the 10 cancers found during the study period, four were detected with MRI alone, three with MRI and mammography, and three with mammography alone. The four cancers detected with MRI alone were invasive, while the three cancers detected with mammography alone were in their early stages.
The addition of MRI to the screening process resulted in a 4.4 percent incremental cancer detection rate. A combination of MRI and mammography produced the highest sensitivity for detecting breast cancers.
"Our results support existing recommendations for annual screening MRI as an adjunct to annual mammography in women with a history of chest irradiation," Dr. Sung said.
Despite clear evidence of MRI's benefits, previous research by Dr. Sung's colleague and study co-author Kevin Oeffinger, M.D., showed that very few women ages 40 to 50 with a history of chest irradiation had undergone screening breast MRIs. Lack of awareness and limited insurance coverage are possible reasons, according to Dr. Sung. MRI is considerably more expensive than mammography.
"We hope our study and other research will bring more attention to the fact that MRI helps detect more cancers," Dr. Sung said. "We would like to see more high-risk patients undergo screening MRI."
"Screening Breast MR Imaging in Women with a History of Chest Irradiation" Collaborating with Dr. Sung were Carol H. Lee, M.D., Elizabeth A. Morris, M.D., Kevin C. Oeffinger, M.D., and D. David Dershaw, M.D.
Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)
RSNA is an association of more than 46,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill. (RSNA.org)
For patient-friendly information on breast cancer screening and MRI, visit RadiologyInfo.org.
Linda Brooks | EurekAlert!
How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego
22.03.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
22.03.2017 | Materials Sciences
22.03.2017 | Physics and Astronomy
22.03.2017 | Materials Sciences