Scientists say the finding, appearing early online in the journal Cancer, supports routine, early prostate-specific antigen (PSA) screening among healthy men with normal life expectancy – a practice several studies have recently questioned.
"There has been some controversy over the value of PSA screening beginning at age 40, but the data from this study strongly suggests that early screening can help us stratify patients' risk and identify those who need to be followed most closely from this younger age group. That, in turn, may help save lives," says Judd W. Moul, MD, Professor of Urologic Surgery and Director of the Duke Prostate Center and senior author of the paper.
Researchers used the Duke Prostate Center database to identify 4,568 men who had PSA tests during the past 20 years and who were diagnosed with prostate cancer. Investigators tracked the patients' age and race and analyzed each variable to assess any association with risk of death from prostate cancer or other causes.
The median age of the men at baseline was 65. The median baseline PSA was 4.5, and the average follow-up period was over nine years. Researchers found that 3.5 percent of the men died from prostate cancer during the study period, while more than 20 percent died from other causes.
Analysis showed that men with a baseline PSA of less than 4 had a very low risk of death from prostate cancer. Investigators also found that men with a score of 4 to 9.9 were three times more likely to die from prostate cancer than those with lower scores. And those with baseline values of greater than 10 were 11 times more likely to die from prostate cancer than were men with PSAs under 2.5.
African-American race and increasing age were also associated with a higher risk of death from prostate cancer and death from other causes.
The American Urological Association recommends all men should have a baseline PSA test at age 40. Duke researchers say the initial test value can be used to assess a man's future risk for prostate cancer.
"The most important result from our study was that baseline PSA was a future predictor of death from prostate cancer," says Ping Tang, MD, a member of the Duke Prostate Center and the department of urology at Guangzhou First Municipal People's Hospital, Guangdong, China, and the lead author of the study. "It's commonly held that men over the age of 75 don't need to bother with PSA screening any longer, but this tells us that chronological age alone may not be enough. Patients need to take into account their initial baseline value, and if it's over 4, continuous screening may be beneficial."
Financial support for the study came from the Department of Defense, an American Urological Association Foundation/Astellas Rising Star in Urology Award and the Committee for Urologic Research, Education and Development at Duke.
Several colleagues from the Duke Prostate Center contributed to the study, including Leon Sun, Vladimir Mouraview, Matthew Uhlman, Thomas Polascik and Stephen Freedland.
Michellle Gailiun | EurekAlert!
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences