Scientists say the finding, appearing early online in the journal Cancer, supports routine, early prostate-specific antigen (PSA) screening among healthy men with normal life expectancy – a practice several studies have recently questioned.
"There has been some controversy over the value of PSA screening beginning at age 40, but the data from this study strongly suggests that early screening can help us stratify patients' risk and identify those who need to be followed most closely from this younger age group. That, in turn, may help save lives," says Judd W. Moul, MD, Professor of Urologic Surgery and Director of the Duke Prostate Center and senior author of the paper.
Researchers used the Duke Prostate Center database to identify 4,568 men who had PSA tests during the past 20 years and who were diagnosed with prostate cancer. Investigators tracked the patients' age and race and analyzed each variable to assess any association with risk of death from prostate cancer or other causes.
The median age of the men at baseline was 65. The median baseline PSA was 4.5, and the average follow-up period was over nine years. Researchers found that 3.5 percent of the men died from prostate cancer during the study period, while more than 20 percent died from other causes.
Analysis showed that men with a baseline PSA of less than 4 had a very low risk of death from prostate cancer. Investigators also found that men with a score of 4 to 9.9 were three times more likely to die from prostate cancer than those with lower scores. And those with baseline values of greater than 10 were 11 times more likely to die from prostate cancer than were men with PSAs under 2.5.
African-American race and increasing age were also associated with a higher risk of death from prostate cancer and death from other causes.
The American Urological Association recommends all men should have a baseline PSA test at age 40. Duke researchers say the initial test value can be used to assess a man's future risk for prostate cancer.
"The most important result from our study was that baseline PSA was a future predictor of death from prostate cancer," says Ping Tang, MD, a member of the Duke Prostate Center and the department of urology at Guangzhou First Municipal People's Hospital, Guangdong, China, and the lead author of the study. "It's commonly held that men over the age of 75 don't need to bother with PSA screening any longer, but this tells us that chronological age alone may not be enough. Patients need to take into account their initial baseline value, and if it's over 4, continuous screening may be beneficial."
Financial support for the study came from the Department of Defense, an American Urological Association Foundation/Astellas Rising Star in Urology Award and the Committee for Urologic Research, Education and Development at Duke.
Several colleagues from the Duke Prostate Center contributed to the study, including Leon Sun, Vladimir Mouraview, Matthew Uhlman, Thomas Polascik and Stephen Freedland.
Michellle Gailiun | EurekAlert!
Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy