Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Baseline PSA predicts risk of death from prostate cancer

Men who have a baseline PSA value of 10 or higher the first time they are tested are up to 11 times more likely to die from prostate cancer than are men with lower initial values, according to Duke University Medical Center researchers.

Scientists say the finding, appearing early online in the journal Cancer, supports routine, early prostate-specific antigen (PSA) screening among healthy men with normal life expectancy – a practice several studies have recently questioned.

"There has been some controversy over the value of PSA screening beginning at age 40, but the data from this study strongly suggests that early screening can help us stratify patients' risk and identify those who need to be followed most closely from this younger age group. That, in turn, may help save lives," says Judd W. Moul, MD, Professor of Urologic Surgery and Director of the Duke Prostate Center and senior author of the paper.

Researchers used the Duke Prostate Center database to identify 4,568 men who had PSA tests during the past 20 years and who were diagnosed with prostate cancer. Investigators tracked the patients' age and race and analyzed each variable to assess any association with risk of death from prostate cancer or other causes.

The median age of the men at baseline was 65. The median baseline PSA was 4.5, and the average follow-up period was over nine years. Researchers found that 3.5 percent of the men died from prostate cancer during the study period, while more than 20 percent died from other causes.

Analysis showed that men with a baseline PSA of less than 4 had a very low risk of death from prostate cancer. Investigators also found that men with a score of 4 to 9.9 were three times more likely to die from prostate cancer than those with lower scores. And those with baseline values of greater than 10 were 11 times more likely to die from prostate cancer than were men with PSAs under 2.5.

African-American race and increasing age were also associated with a higher risk of death from prostate cancer and death from other causes.

The American Urological Association recommends all men should have a baseline PSA test at age 40. Duke researchers say the initial test value can be used to assess a man's future risk for prostate cancer.

"The most important result from our study was that baseline PSA was a future predictor of death from prostate cancer," says Ping Tang, MD, a member of the Duke Prostate Center and the department of urology at Guangzhou First Municipal People's Hospital, Guangdong, China, and the lead author of the study. "It's commonly held that men over the age of 75 don't need to bother with PSA screening any longer, but this tells us that chronological age alone may not be enough. Patients need to take into account their initial baseline value, and if it's over 4, continuous screening may be beneficial."

Financial support for the study came from the Department of Defense, an American Urological Association Foundation/Astellas Rising Star in Urology Award and the Committee for Urologic Research, Education and Development at Duke.

Several colleagues from the Duke Prostate Center contributed to the study, including Leon Sun, Vladimir Mouraview, Matthew Uhlman, Thomas Polascik and Stephen Freedland.

Michellle Gailiun | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>