A new drug for patients with acute myeloid leukemia (AML) marked by a specific type of genetic mutation has shown surprising promise in a Phase II clinical trial.
Long-term survival from the therapy is still unknown, Levis says, but of the group of 137 patients, 47 (34 percent) were able to receive a transplant after responding to quizartinib. Some of these patients have survived two years after treatment with no disease recurrence.
Based on results, the company that makes the drug, Ambit Biosciences, is planning larger Phase III trials, in which patients who have the FLT3 mutation will receive either quizartinib or chemotherapy after random grouping. Meanwhile, Levis and other physicians are continuing to study the drug in a clinical trial testing lower doses.
The centers participating in the trial were: Abramson Cancer Center, University of Pennsylvania; Hôpital Saint-Louis, Université Paris; University Hospital of Ulm, Germany; Goethe University of Frankfurt, Germany; Hopital de Versailles, Le Chesnay, France; Bologna University School of Medicine, Italy; University of Washington, Seattle; Cardiff University School of Medicine, United Kingdom; University of Texas MD Anderson Cancer Center, Houston. Levis is a consultant for Ambit Biosciences Inc., manufacturers of quizartinib (AC220). This relationship has been disclosed and is under the management of the Johns Hopkins University School of Medicine Conflict of Interest Committee.
Vanessa Wasta | EurekAlert!
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