Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A clue to the GI problems that plague many kids with autism?

12.01.2012
New study finds that children with autism and gastrointestinal symptoms have high levels of the bacterium Sutterella in their gut

New research conducted in the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health, reports that children with autism and gastrointestinal disturbances have high levels of a bacterium called Sutterella in their intestines.

Study findings are published online in the journal mBio.

The investigators found that over half of the children diagnosed with autism and gastrointestinal disturbances had Sutterella in intestinal biopsy tissue, while Sutterella was absent in biopsies from typically developing children with gastrointestinal disturbances. Not only was Sutterella present in the intestines of children with autism, but relative to most genera of bacteria, Sutterella was present at remarkably high levels. Sutterella species have been isolated from human infections previous to this study, but it remains unclear whether this bacterium is a human pathogen.

"These findings shine a light on a bacterium about which we know very little, in a disorder for which we have few answers," says Brent Williams, PhD, the lead author on the study. "There is much work to be done toward understanding the role Sutterella plays in autism, the microbiota, infections, and inflammation."

The researchers examined intestinal biopsies from 32 patients, 23 diagnosed with autism and 9 typically developing children. While previous studies investigating a link between the microbiota and autism have utilized stool samples, the study was unique in investigating bacteria adherent to the intestinal wall, which may be different than what is shed in the stool. Furthermore, the researchers designed and applied novel Sutterella-specific molecular assays to enable detection, quantitation, and phylogenetic analysis of Sutterella species in biological and environmental samples.

Many children with autism have gastrointestinal problems that can complicate clinical management and contribute to behavioral disturbances. However, the underlying reason that autism is associated with gastrointestinal disturbances is unknown.

"Although caution in interpretation is indicated because this is a small cohort, microbiome research may provide new insights into gastrointestinal disturbances that develop in children with autism," notes Mady Hornig, MD, Mailman School associate professor and director of Translational Research at the CII.

About Columbia University's Mailman School of Public Health

Founded in 1922 as one of the first three public health academies in the nation, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 300 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,000 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including the International Center for AIDS Care and Treatment Programs (ICAP), the National Center for Disaster Preparedness, and the Center for Infection and Immunity. For more information, please visit www.mailman.columbia.edu

Stephanie Berger | EurekAlert!
Further information:
http://www.columbia.edu

Further reports about: Infection chronic disease health services immunity public health

More articles from Health and Medicine:

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

nachricht Improving memory with magnets
28.03.2017 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Periodic ventilation keeps more pollen out than tilted-open windows

29.03.2017 | Health and Medicine

Researchers discover dust plays prominent role in nutrients of mountain forest ecoystems

29.03.2017 | Earth Sciences

OLED production facility from a single source

29.03.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>