By comparing these two functional images, physicians may be able to better diagnose and treat patients with brain disorders
Philadelphia, PA) - Clinical researchers from the University of Pennsylvania Health System (UPHS) are the first to combine fMRI and PET scanning in radiology, creating a way to compare different measurements of the brain’s function concurrently. This analysis could lead to better diagnosis and treatment in patients suffering from brain disorders, like Alzheimer’s disease.
"By using these two established methods, we now have an integrated way to look at the brain’s functions," explained Andrew Newberg, MD, a radiologist in nuclear medicine at UPHS and lead author on this clinical study. "We can now get a more comprehensive view of what’s happening in the brain at a particular time, than we’ve ever been able to do before. We can look at more diseases and more activation states."
The work combines the functional imaging of fMRI (functional magnetic resonance imaging), which captures the blood flow in the brain, and PET scanning (positron emission tomography), which looks at the glucose metabolism in the brain. "Normally, these two measures are coupled, or paired together. The more metabolism you have, the more blood flow," adds Newberg. "But there are times the two don’t match up with each other like with stroke, seizure disorders, or neurodegenerative disorders. That’s what led us to this new technique so that we can explore many different aspects of the brain’s function."
So how does this new simultaneous imaging approach actually work? Radiologists inject a patient with radioactive material used for a PET scan WHILE the patient is already inside an fMRI scanner. During the time that material is being taken up in the brain, radiologists are acquiring the fMRI image. Then, when that is complete, radiologists take the patient immediately to the PET scanner, to retrieve the PET image.
"We have both machines available to us and have now put them together in a way that works," adds Newberg. "We can take the results of the simultaneous fMRI and PET scans and come up with two separate results and compare them for a new look at the brain. Using this technique, you capture the exact same moment in the brain with both scans. It will help to show us what the relationship is between metabolism and blood flow. Do those two really match up in large majority of conditions?"
Newberg said one goal of this new simultaneous fMRI-PET scan is to better understand the effect of certain medications on the brain and body. The clinical research for this study has been conducted through the PET Center at the Hospital of the University of Pennsylvania and through the Center for Functional Neuroimaging (CFN), known for its excellence in multi-disciplinary brain imaging.
Susanne Hartman | EurekAlert!
A Challenging European Research Project to Develop New Tiny Microscopes
28.03.2017 | Technische Universität Braunschweig
3-D visualization of the pancreas -- new tool in diabetes research
15.03.2017 | Umea University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences