By comparing these two functional images, physicians may be able to better diagnose and treat patients with brain disorders
Philadelphia, PA) - Clinical researchers from the University of Pennsylvania Health System (UPHS) are the first to combine fMRI and PET scanning in radiology, creating a way to compare different measurements of the brain’s function concurrently. This analysis could lead to better diagnosis and treatment in patients suffering from brain disorders, like Alzheimer’s disease.
"By using these two established methods, we now have an integrated way to look at the brain’s functions," explained Andrew Newberg, MD, a radiologist in nuclear medicine at UPHS and lead author on this clinical study. "We can now get a more comprehensive view of what’s happening in the brain at a particular time, than we’ve ever been able to do before. We can look at more diseases and more activation states."
The work combines the functional imaging of fMRI (functional magnetic resonance imaging), which captures the blood flow in the brain, and PET scanning (positron emission tomography), which looks at the glucose metabolism in the brain. "Normally, these two measures are coupled, or paired together. The more metabolism you have, the more blood flow," adds Newberg. "But there are times the two don’t match up with each other like with stroke, seizure disorders, or neurodegenerative disorders. That’s what led us to this new technique so that we can explore many different aspects of the brain’s function."
So how does this new simultaneous imaging approach actually work? Radiologists inject a patient with radioactive material used for a PET scan WHILE the patient is already inside an fMRI scanner. During the time that material is being taken up in the brain, radiologists are acquiring the fMRI image. Then, when that is complete, radiologists take the patient immediately to the PET scanner, to retrieve the PET image.
"We have both machines available to us and have now put them together in a way that works," adds Newberg. "We can take the results of the simultaneous fMRI and PET scans and come up with two separate results and compare them for a new look at the brain. Using this technique, you capture the exact same moment in the brain with both scans. It will help to show us what the relationship is between metabolism and blood flow. Do those two really match up in large majority of conditions?"
Newberg said one goal of this new simultaneous fMRI-PET scan is to better understand the effect of certain medications on the brain and body. The clinical research for this study has been conducted through the PET Center at the Hospital of the University of Pennsylvania and through the Center for Functional Neuroimaging (CFN), known for its excellence in multi-disciplinary brain imaging.
Susanne Hartman | EurekAlert!
Surgery involving ultrasound energy found to treat high blood pressure
24.05.2018 | Queen Mary University of London
XXL computed tomography: a new dimension in X-ray analysis
17.05.2018 | Fraunhofer-Gesellschaft
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy