“We wanted to determine which patients with newly diagnosed breast cancer would benefit most from preoperative fine needle aspiration of the axillary lymph nodes,” said Martha Mainiero, MD, lead author of the study.
“This quick and minimally invasive procedure can assist the surgeon in determining what type of axillary surgery is best for patients with breast cancer. Unfortunately many centers do not routinely perform this procedure as there is not yet consensus on who will benefit from it,” she said.
The study consisted of USFNA of axillary lymph nodes in 224 breast cancer patients. The researchers measured the cortical thickness of each lymph node that was aspirated. They found that using a cortical thickness measurement of 3mm to determine who gets USFNA would result in the most optimum combination of diagnosing metastatic disease preoperatively while minimizing unnecessary USFNA.
Patients in the study had primary tumor sizes ranging from 0-12 cm with a mean of 1.9cm and included 159 tumors that measured less than or equal to 2 cm and 65 tumors that were greater than 2 cm. The use of USFNA was positive in 52 patients (23%). If USFNA were limited only to axillary lymph nodes with a cortical thickness of 3 mm or more, USFNA positivity would have increased to 49%.
“With these results, this procedure may become more widely used and save patients unnecessary surgery,” said Dr. Mainiero. “This cut-off provided the most optimum combination in detecting metastatic disease while minimizing negative USFNA results,” she said.
Necoya Tyson | EurekAlert!
PET identifies which prostate cancer patients can benefit from salvage radiation treatment
05.12.2017 | Society of Nuclear Medicine and Molecular Imaging
Designing a golden nanopill
01.12.2017 | University of Texas at Austin, Texas Advanced Computing Center
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
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