Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mammography reduces mortality from breast cancer in ages 40–49 years

30.09.2010
Mammography examinations of women aged 40–49 reduce breast cancer mortality by 29%, a statistically significant reduction. This is shown in the Umeå-directed national SCRY Study in Sweden, which is the largest study of its kind ever performed anywhere in the world.

X-ray examination of all women’s breasts with the aim of discovering breast cancer, so-called mammography screening, saves the lives of many women each year in that tumors are found early and can therefore be treated early.

However, a lower age limit for mammography screening is necessary, as younger women run a lower risk of developing breast cancer, which means that more women would have to undergo mammography in order to save the corresponding number of lives. What’s more, mammography works less well in younger women.

The SCRY Study (mammography SCReening of Young women) compares breast cancer mortality between a study group consisting of those counties/municipalities that have invited the age group and a control group consisting of areas that have only invited women aged 50 and older. Only deaths caused by breast cancer in the ages of 40–49 were counted. The average follow-up period was 16 years for both the study group and the control group. The study is the largest ever undertaken for the 40–49 age group in the world. Data from the cancer registry and the cause of death registry have been used. Further, individual data from screening centers throughout Sweden have been gathered, making it possible to study the effect both on women who were offered mammography and on women who actually participated.

The study covers the entire country. It comprises 803 breast cancer deaths over 7.3 million person years in the study group (which underwent mammography) and 1,238 breast cancer deaths over 8.8 million person years in the control group. The mean number of women aged 40–49 years in Sweden during the study period was 600,000. The study shows that breast cancer mortality was 26% lower for those who were invited to mammography screening compared with those who were not. Those who actually participated in mammography screening had a 29% lower breast cancer mortality rate than those who were not invited to screening. The findings are statistically significant.

A comparison between the group that underwent mammography and the control group that was undertaken for a period before screening started uncovered no statistically significant difference in breast cancer mortality. Breast cancer care in Sweden has moreover been further standardized since that time, not least as a result of care programs and national guidelines. This indicates that the difference in breast cancer mortality is a result of access to mammography screening among 40–49-year-olds.

There is a consensus today that mammography screening for the 50–69-year age group reduces breast cancer mortality. Calling in women aged 40–49 years for mammography screening, on the other hand, has been controversial and much debated since the 1980s, when mammography screening began. Few studies have been able to show any significant effect on mortality in the age group. At the same time, few studies have been designed to study the age group in particular. The Swedish National Board of Health and Welfare recommends screening for the entire age interval of 40–74 years, whereas EU guidelines do not include 40–49-year-olds in their recommendations. In the U.S., the U.S. Preventive Services Task Force (USPSTF) recently changed its recommendations not to include the 40–49 age group.

Originally the Swedish National Board of Health and Welfare recommended that women aged 40–69 years should be called in for screening. Soon after, these recommendations were changed to focus on women between the ages of 50 and 74. As a result, for a long period roughly half of Swedish counties and municipalities have called in 40–49-year-olds for screening, while about half have chosen to call in only women aged 50 and over.

For more information, please contact Barbro Hellquist, doctoral candidate at the Department of Radiation Sciences, Oncology, Umeå University. She can be reached at: Telephone: +46 (0)90-785 48 49 E-mail barbro.hellquist@oc.umu.se

Pressofficer Bertil Born; +46-703 886 058; bertil.born@adm.umu.se

Bertil Born | idw
Further information:
http://onlinelibrary.wiley.com/doi/10.1002/cncr.25650/full
http://www.vr.se

More articles from Medical Engineering:

nachricht Virtual Reality in Medicine: New Opportunities for Diagnostics and Surgical Planning
07.12.2016 | Universität Basel

nachricht 3-D printed kidney phantoms aid nuclear medicine dosing calibration
06.12.2016 | Society of Nuclear Medicine

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>